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Construction of a high-density genetic map and quantitative trait locus mapping in the sea cucumber <i>Apostichopus japonicus</i>. <i>NPG Scientific Reports 5(14852 )</i>: 11 pp. <a href=\"http://dx.doi.org/10.1038/srep14852\" target=\"_blank\">http://dx.doi.org/10.1038/srep14852</a>","BEntID":242236,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 5(14852 )</i>: 11 pp. <a href=\"http://dx.doi.org/10.1038/srep14852\" target=\"_blank\">http://dx.doi.org/10.1038/srep14852</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tian, M.; Li, Y.; Jing, J.; Mu, C.; Du, H.; Dou, J.; Mao, J.; Li, X.; Jiao, W.; Wang, Y.; Hu, X.; Wang, S.; Wang, R.; Bao, Z.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tian, M. <i>et al.</i>","Englishabstract":"Genetic linkage maps are critical and indispensable tools in a wide range of genetic and genomic research. With the advancement of genotyping-by-sequencing (GBS) methods, the construction of a high-density and high-resolution linkage maps has become achievable in marine organisms lacking sufficient genomic resources, such as echinoderms. In this study, high-density, high-resolution genetic map was constructed for a sea cucumber species, Apostichopus japonicus, utilizing the 2b-restriction site-associated DNA (2b-RAD) method. A total of 78<sub>39</sub> markers were anchored to the linkage map with the map coverage of 99.57%, to our knowledge, this is the highest marker density among echinoderm species. QTL mapping and association analysis consistently captured one growth-related QTL located in a 5cM region of linkage group (LG) <sub>5</sub>. An annotated candidate gene, retinoblastoma-binding protein 5 (RbBP<sub>5</sub>), which has been reported to be an important regulator of cell proliferation, was recognized in the QTL region. This linkage map represents a powerful tool for research involving both fine-scale QTL mapping and marker assisted selection (MAS), and will facilitate chromosome assignment and improve the whole-genome assembly of sea cucumber in the future.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Construction of a high-density genetic map and quantitative trait locus mapping in the sea cucumber <i>Apostichopus japonicus</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-13 01:31:23.978957","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2015-10-16","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000362279200001","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/srep14852"},"refs":null,"anarec":{"AnaID":250542,"PubliDate":2015,"Pagination":"11 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"5","Issue":"14852 ","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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