{"refrec":{"BRefID":253600,"RR":"<b>Dwyer, L.; Parkin-Smith, G.F.; Brantingham, J.W.; Korporaal, C.; Cassa, T.K.; Globe, G.; Bonnefin, D.; Tong, V.</b> (2015). Manual and manipulative therapy in addition to rehabilitation for osteoarthritis of the knee: assessor-blind randomized pilot trial. <i>J. Manipulative Physiol. Ther. 38(1)</i>: 1-21. <a href=\"https://dx.doi.org/10.1016/j.jmpt.2014.10.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.jmpt.2014.10.002</a>","BEntID":245413,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Manipulative Physiol. Ther. 38(1)</i>: 1-21. <a href=\"https://dx.doi.org/10.1016/j.jmpt.2014.10.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.jmpt.2014.10.002</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Dwyer, L.; Parkin-Smith, G.F.; Brantingham, J.W.; Korporaal, C.; Cassa, T.K.; Globe, G.; Bonnefin, D.; Tong, V.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Dwyer, L. <i>et al.</i>","Englishabstract":"ObjectivesThe purpose of this study was to examine the methodological integrity, sample size requirements, and short-term preliminary clinical outcomes of manual and manipulative therapy (MMT) in addition to a rehabilitation program for symptomatic knee osteoarthritis (OA).MethodsThis was a pilot study of an assessor-blinded, randomized, parallel-group trial in 2 independent university-based outpatient clinics. Participants with knee OA were randomized to 3 groups: 6 MMT sessions alone, training in rehabilitation followed by a home rehabilitation program alone, or MMT plus the same rehabilitation program, respectively. Six MMT treatment sessions (provided by a chiropractic intern under supervision or by an experienced chiropractor) were provided to participants over the 4-week treatment period. The primary outcome was a description of the research methodology and sample size estimation for a confirmatory study. The secondary outcome was the short-term preliminary clinical outcomes. Data were collected at baseline and 5 weeks using the Western Ontario and McMasters Osteoarthritis Index questionnaire, goniometry for knee flexion/extension, and the McMaster Overall Therapy Effectiveness inventory. Analysis of variance was used to compare differences between groups.ResultsEighty-three patients were randomly allocated to 1 of the 3 groups (27, 28, and 28, respectively). Despite 5 dropouts, the data from 78 participants were available for analysis with 10% of scores missing. A minimum of 462 patients is required for a confirmatory 3-arm trial including the respective interventions, accounting for cluster effects and a 20% dropout rate. Statistically significant and clinically meaningful changes in scores from baseline to week 5 were found for all groups for the Western Ontario and McMasters Osteoarthritis Index (P = .008), with a greater change in scores for MMT and MMT plus rehabilitation. Between-group comparison did not reveal statistically significant differences between group scores at week 5 for any of the outcome measures (P = .46).ConclusionsThis pilot trial suggests that a confirmatory trial is feasible. There were significant changes in scores from baseline to week 5 across all groups, suggesting that all 3 treatment approaches may be of benefit to patients with mild-to-moderate knee OA, justifying a confirmatory trial to compare these interventions.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Manual and manipulative therapy in addition to rehabilitation for osteoarthritis of the knee: assessor-blind randomized pilot trial","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-20 01:32:39.462040","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"    Pilot Projects; Osteoarthritis; Knee; Musculoskeletal Manipulations; Rehabilitation","OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2017-05-16","DateCreate":"2016-03-06","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000346644800001","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.jmpt.2014.10.002"},"refs":null,"anarec":{"AnaID":253600,"PubliDate":2015,"Pagination":"1-21","XtraPublOfAnaID":null,"ISBN":null,"Volume":"38","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":253779,"SerRR":"Journal of Manipulative and Physiological Therapeutics. Elsevier: New York.  ISSN 0161-4754; e-ISSN 1532-6586","StandardTitleSer":"Journal of Manipulative and Physiological Therapeutics","ISSN":"0161-4754","AbbrevSer":"J. Manipulative Physiol. 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