{"refrec":{"BRefID":254545,"RR":"<b>Cornejo-Castillo, F.M.; Cabello, A.M.; Salazar, G.; Sánchez-Baracaldo, P.; Lima-Mendez, G.; Hingamp, P.; Alberti, A.; Sunagawa, S.; Bork, P.; de Vargas, C.; Raes, J.; Bowler, C.; Wincker, P.; Zehr, J.P.; Gasol, J.M.; Massana, R.; Acinas, S.G.</b> (2016). Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton. <i>Nature Comm. 7(11071)</i>. <a href=\"http://dx.doi.org/10.1038/ncomms11071\" target=\"_blank\">http://dx.doi.org/10.1038/ncomms11071</a>","BEntID":246550,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 7(11071)</i>. <a href=\"http://dx.doi.org/10.1038/ncomms11071\" target=\"_blank\">http://dx.doi.org/10.1038/ncomms11071</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Cornejo-Castillo, F.M.; Cabello, A.M.; Salazar, G.; Sánchez-Baracaldo, P.; Lima-Mendez, G.; Hingamp, P.; Alberti, A.; Sunagawa, S.; Bork, P.; de Vargas, C.; Raes, J.; Bowler, C.; Wincker, P.; Zehr, J.P.; Gasol, J.M.; Massana, R.; Acinas, S.G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Cornejo-Castillo, F.M. <i>et al.</i>","Englishabstract":"The unicellular cyanobacterium UCYN-A, one of the major contributors to nitrogen fixation in the open ocean, lives in symbiosis with single-celled phytoplankton. UCYN-A includes several closely related lineages whose partner fidelity, genome-wide expression and time of evolutionary divergence remain to be resolved. Here we detect and distinguish UCYN-A1 and UCYN-A2 lineages in symbiosis with two distinct prymnesiophyte partners in the South Atlantic Ocean. Both symbiotic systems are lineage specific and differ in the number of UCYN-A cells involved. Our analyses infer a streamlined genome expression towards nitrogen fixation in both UCYN-A lineages. Comparative genomics reveal a strong purifying selection in UCYN-A1 and UCYN-A2 with a diversification process ~91 Myr ago, in the late Cretaceous, after the low-nutrient regime period occurred during the Jurassic. These findings suggest that UCYN-A diversified in a co-evolutionary process, wherein their prymnesiophyte partners acted as a barrier driving an allopatric speciation of extant UCYN-A lineages.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-22 01:31:50.853726","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2016,"MonPub":null,"DateUpdate":"2016-06-12","DateCreate":"2016-03-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000372586800001","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/ncomms11071"},"refs":null,"anarec":{"AnaID":254545,"PubliDate":2016,"Pagination":null,"XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"11071","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. 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