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The Atlantic salmon genome provides insights into rediploidization. <i>Nature (Lond.) 533(7602)</i>: 200-205. <a href=\"http://dx.doi.org/10.1038/nature17164\" target=\"_blank\">http://dx.doi.org/10.1038/nature17164</a>","BEntID":247795,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature (Lond.) 533(7602)</i>: 200-205. <a href=\"http://dx.doi.org/10.1038/nature17164\" target=\"_blank\">http://dx.doi.org/10.1038/nature17164</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lien, S.; Koop, B.F.; Sandve, S.R.; Miller, J.R.; Kent, M.P.; Nome, T.; Hvidsten, T.R.; Leong, J.S.; Minkley, D.R.; Zimin, A.; Grammes, F.; Grove, H.; Gjuvsland, A.; Walenz, B.; Hermansen, R.A.; von Schalburg, K.; Rondeau, E.B.; Di Genova, A.; Samy, J.K.A.; Olav Vik, J.; Vigeland, M.D.; Caler, L.; Grimholt, U.; Jentoft, S.; Våge, D.I.; de Jong, P.J.; Moen, T.; Baranski, M.; Palti, Y.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lien, S. <i>et al.</i>","Englishabstract":"The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (<i>Salmo salar</i>), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial for the post-Ss4R rediploidization process. Comparisons of duplicate gene expression patterns across a wide range of tissues with orthologous genes from a pre-Ss4R outgroup unexpectedly demonstrate far more instances of neofunctionalization than subfunctionalization. Surprisingly, we find that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products. Finally, we demonstrate that the Atlantic salmon assembly can serve as a reference sequence for the study of other salmonids for a range of purposes.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The Atlantic salmon genome provides insights into rediploidization","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-02 01:31:29.207112","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2016,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2016-05-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000376007200040","VABBcode":null,"OpenAcc":0,"DOI":"10.1038/nature17164"},"refs":null,"anarec":{"AnaID":255786,"PubliDate":2016,"Pagination":"200-205","XtraPublOfAnaID":null,"ISBN":null,"Volume":"533","Issue":"7602","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43431,"SerRR":"Nature: International Weekly Journal of Science. 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