{"refrec":{"BRefID":256899,"RR":"<b>Busschaert, P.; Frans, I.; Crauwels, S.; Zhu, B.; Willems, K.; Bossier, P.; Michiels, C.; Verstrepen, K.; Lievens, B.; Rediers, H.</b> (2015). Comparative genome sequencing to assess the genetic diversity and virulence attributes of 15 <i>Vibrio anguillarum</i> isolates. <i>J. Fish Dis. 38(9)</i>: 795-807. <a href=\"https://dx.doi.org/10.1111/jfd.12290\" target=\"_blank\">https://dx.doi.org/10.1111/jfd.12290</a>","BEntID":248908,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Fish Dis. 38(9)</i>: 795-807. <a href=\"https://dx.doi.org/10.1111/jfd.12290\" target=\"_blank\">https://dx.doi.org/10.1111/jfd.12290</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Busschaert, P.; Frans, I.; Crauwels, S.; Zhu, B.; Willems, K.; Bossier, P.; Michiels, C.; Verstrepen, K.; Lievens, B.; Rediers, H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Busschaert, P. <i>et al.</i>","Englishabstract":"<i>Vibrio anguillarum</i> is the causative agent of vibriosis, a deadly haemorrhagic septicaemic disease affecting various marine and fresh/brackish water fish, bivalves and crustaceans. However, the diversity and virulence mechanisms of this pathogen are still insufficiently known. In this study, we aimed to increase our understanding of <i>V. anguillarum</i> diversity and virulence through comparative genome analysis of 15 <i>V. anguillarum</i> strains, obtained from different hosts or non-host niches and geographical regions, among which 10 and 5 strains were found to be virulent and avirulent, respectively, against sea bass larvae. First, the 15 draft genomes were annotated and screened for putative virulence factors, including genes encoding iron uptake systems, transport systems and non-ribosomal peptide synthetases. Second, comparative genome analysis was performed, focusing on single nucleotide polymorphisms (SNPs) and small insertions and deletions (InDels). Five <i>V. anguillarum</i> strains showed a remarkably high nucleotide identity. However, these strains comprise both virulent and avirulent strains towards sea bass larvae, suggesting that differences in virulence may be caused by subtle nucleotide variations. Clearly, the draft genome sequence of these 15 strains represents a starting point for further genetic research of this economically important fish pathogen.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Comparative genome sequencing to assess the genetic diversity and virulence attributes of 15 <i>Vibrio anguillarum</i> isolates","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-25 01:32:14.671911","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"comparative genomics; fish pathogen; Vibrio anguillarum; geneticdiversity; virulence","OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2020-06-24","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000359418400003","VABBcode":"vabb:384240","OpenAcc":0,"DOI":"10.1111/jfd.12290"},"refs":null,"anarec":{"AnaID":256899,"PubliDate":2015,"Pagination":"795-807","XtraPublOfAnaID":null,"ISBN":null,"Volume":"38","Issue":"9","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44476,"SerRR":"Journal of Fish Diseases. Blackwell Science: Oxford; London; Edinburgh; Boston; Melbourne.  ISSN 0140-7775; e-ISSN 1365-2761","StandardTitleSer":"Journal of Fish Diseases","ISSN":"0140-7775","AbbrevSer":"J. Fish Dis.","StandardTitleMon":null,"StartPage":795,"Pages":13,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Busschaert","Firstname":null,"Initials":"P.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220781,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":null,"PersID":35882,"InsID":13811},{"AutName":"Frans","Firstname":null,"Initials":"I.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220782,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":null,"PersID":31526,"InsID":13811},{"AutName":"Crauwels","Firstname":null,"Initials":"S.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220783,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":null,"PersID":34090,"InsID":13811},{"AutName":"Zhu","Firstname":null,"Initials":"B.","Affiliation":"VIB Lab for Systems Biology","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220784,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"PSB","InsFSN":"Flanders Institute for Biotechnology; VIB-Ugent Center for Plant Systems Biology","ORCID":null,"PersID":null,"InsID":7968},{"AutName":"Willems","Firstname":null,"Initials":"K.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220786,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":null,"PersID":28643,"InsID":13811},{"AutName":"Bossier","Firstname":"Peter","Initials":"P.","Affiliation":"Laboratory of Aquaculture & Artemia Reference Centre, Department of Animal Production, Faculty of Bioscience Engineering, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":232458,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"ARC","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Aquacultuur en Artemia Reference Center","ORCID":"0000-0002-6165-9111","PersID":125,"InsID":22},{"AutName":"Michiels","Firstname":null,"Initials":"C.","Affiliation":"Centre for Food and Microbial Technology, M2S, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220789,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Centre for Food and Microbial Technology","ORCID":"0000-0002-7710-6802","PersID":34533,"InsID":13809},{"AutName":"Verstrepen","Firstname":null,"Initials":"K.","Affiliation":"VIB Lab for Systems Biology","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220790,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"PSB","InsFSN":"Flanders Institute for Biotechnology; VIB-Ugent Center for Plant Systems Biology","ORCID":null,"PersID":null,"InsID":7968},{"AutName":"Lievens","Firstname":null,"Initials":"B.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220792,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":null,"PersID":34091,"InsID":13811},{"AutName":"Rediers","Firstname":null,"Initials":"H.","Affiliation":"Laboratory for Process Microbial Ecology and Bioinspirational Management, Cluster for Bioengineering Technology (CBeT), Department of Microbial and Molecular Systems (M2S), KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":248908,"AutID":220793,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Group Science, Engineering and Technology; Department of Microbial and Molecular Systems; Technology Cluster Bioengineering Technology; Laboratory for Process Microbial Ecology and Bioinspirational Management","ORCID":"0000-0001-8645-107X","PersID":34089,"InsID":13811}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":346474,"LibID":36,"BRefID":256899,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"346474","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Blackwell Science","City":"Oxford; London; Edinburgh; Boston; Melbourne"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Vibrio anguillarum"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":248908,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":248908,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1111/jfd.12290","externalID":"10.1111/jfd.12290","URLTypeCode":"DOI","URLID":65803,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Vibrio anguillarum","AphiaID":889990,"TaxtID":34901}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Vibrio anguillarum","DutchTerm":null,"AphiaID":889990,"TaxtID":34901}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2016-05-29 22:57:39.720000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-06-24 09:54:04.263000","timezone_type":3,"timezone":"Europe/Brussels"}}}