{"refrec":{"BRefID":257018,"RR":"<b>Andrys, R; Zurita, J; Zguna, N; Verschueren, K.; De Borggraeve, W.M.; Ilag, L</b> (2015). Improved detection of beta-N-methylamino-L-alanine using N-hydroxysuccinimide ester of N-butylnicotinic acid for the localization of BMAA in blue mussels (<i>Mytilus edulis</i>). <i>Anal. Bioanal. Chem. 407(13)</i>: 3743-3750. <a href=\"https://dx.doi.org/10.1007/s00216-015-8597-2\" target=\"_blank\">https://dx.doi.org/10.1007/s00216-015-8597-2</a>","BEntID":249027,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Anal. Bioanal. Chem. 407(13)</i>: 3743-3750. <a href=\"https://dx.doi.org/10.1007/s00216-015-8597-2\" target=\"_blank\">https://dx.doi.org/10.1007/s00216-015-8597-2</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Andrys, R; Zurita, J; Zguna, N; Verschueren, K.; De Borggraeve, W.M.; Ilag, L","OrigTitleTranslFlag":0,"Authorstringtrunc":"Andrys, R <i>et al.</i>","Englishabstract":"beta-N-Methylamino-l-alanine (BMAA) is an important non-protein amino acid linked to neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS). Because it can be transferred and bioaccumulated higher up the food chain, it poses significant public health concerns; thus, improved detection methods are of prime importance for the identification and management of these toxins. Here, we report the successful use of N-hydroxysuccinimide ester of N-butylnicotinic acid (C-4-NA-NHS) for the efficient separation of BMAA from its isomers and higher sensitivity in detecting BMAA compared to the current method of choice using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. Implementation of this efficient method allowed localization of BMAA in the non-visceral tissues of blue mussels, suggesting that more efficient depuration may be required to remove this toxin prior to consumption. This is a crucial method in establishing the absence or presence of the neurotoxic amino acid BMAA in food, environmental or biomedical samples.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Improved detection of beta-N-methylamino-L-alanine using N-hydroxysuccinimide ester of N-butylnicotinic acid for the localization of BMAA in blue mussels (<i>Mytilus edulis</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-18 01:31:49.659400","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"BMAA; Isomers; Neurotoxin; LC-MS/MS; Improved derivatization; Quaternaryammonium","OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2020-06-24","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000353230400019","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s00216-015-8597-2"},"refs":null,"anarec":{"AnaID":257018,"PubliDate":2015,"Pagination":"3743-3750","XtraPublOfAnaID":null,"ISBN":null,"Volume":"407","Issue":"13","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":65810,"SerRR":"Analytical and Bioanalytical Chemistry. Springer: Heidelberg.  ISSN 1618-2642; e-ISSN 1618-2650","StandardTitleSer":"Analytical and Bioanalytical Chemistry","ISSN":"1618-2642","AbbrevSer":"Anal. Bioanal. Chem.","StandardTitleMon":null,"StartPage":3743,"Pages":8,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Andrys","Firstname":null,"Initials":"R.","Affiliation":"Stockholm Univ, Dept Environm Sci & Analyt Chem, S-10691 Stockholm, Sweden.","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221675,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Zurita","Firstname":null,"Initials":"J.","Affiliation":"Stockholm Univ, Dept Environm Sci & Analyt Chem, S-10691 Stockholm, Sweden.","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221677,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Zguna","Firstname":null,"Initials":"N.","Affiliation":"Stockholm Univ, Dept Environm Sci & Analyt Chem, S-10691 Stockholm, Sweden.","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221678,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Verschueren","Firstname":"Klaas","Initials":"K.","Affiliation":"Department of Chemistry, University of Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221679,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"Katholieke Universiteit Leuven; Departement Chemie","ORCID":null,"PersID":null,"InsID":4683},{"AutName":"De Borggraeve","Firstname":"Wim","Initials":"W.M.","Affiliation":"Department of Chemistry, University of Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221680,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"Katholieke Universiteit Leuven; Departement Chemie","ORCID":"0000-0001-7813-6192","PersID":37236,"InsID":4683},{"AutName":"Ilag","Firstname":null,"Initials":"L.","Affiliation":"Stockholm Univ, Dept Environm Sci & Analyt Chem, S-10691 Stockholm, Sweden.","Discriminator":null,"CorporateFlag":0,"BEntID":249027,"AutID":221681,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":346526,"LibID":36,"BRefID":257018,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"346526","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Springer","City":"Heidelberg"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":249027,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":249027,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1007/s00216-015-8597-2","externalID":"10.1007/s00216-015-8597-2","URLTypeCode":"DOI","URLID":46420,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2016-05-29 23:00:54.050000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-06-24 09:54:04.263000","timezone_type":3,"timezone":"Europe/Brussels"}}}