{"refrec":{"BRefID":257358,"RR":"<b>Mathieu, V.; Wauthoz, N.; Lefranc, F.; Niemann, H.; Amighi, K.; Kiss, R.; Proksch, P.</b> (2013). Cyclic versus hemi-bastadins. Pleiotropic anti-cancer effects: from apoptosis to anti-angiogenic and anti-migratory effects. <i>Molecules 18(3)</i>: 3543-3561. <a href=\"http://dx.doi.org/10.3390/molecules18033543\" target=\"_blank\">http://dx.doi.org/10.3390/molecules18033543</a>","BEntID":249367,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Molecules 18(3)</i>: 3543-3561. <a href=\"https://dx.doi.org/10.3390/molecules18033543\" target=\"_blank\">https://dx.doi.org/10.3390/molecules18033543</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Mathieu, V.; Wauthoz, N.; Lefranc, F.; Niemann, H.; Amighi, K.; Kiss, R.; Proksch, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Mathieu, V. <i>et al.</i>","Englishabstract":"Bastadins-6, -9 and -16 isolated from the marine sponge Ianthella basta displayed in vitro cytostatic and/or cytotoxic effects in six human and mouse cancer cell lines. The in vitro growth inhibitory effects of these bastadins were similar in cancer cell lines sensitive to pro-apoptotic stimuli versus cancer cell lines displaying various levels of resistance to pro-apoptotic stimuli. While about ten times less toxic than the natural cyclic bastadins, the synthetically derived 5,5'-dibromohemibastadin-1 (DBHB) displayed not only in vitro growth inhibitory activity in cancer cells but also anti-angiogenic properties. At a concentration of one tenth of its in vitro growth inhibitory concentration, DBHB displayed actual antimigratory effects in mouse B16F10 melanoma cells without any sign of cytotoxicity and/or growth inhibition. The serum concentration used in the cell culture media markedly influenced the DBHB-induced antimigratory effects in the B16F10 melanoma cell population. 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