{"refrec":{"BRefID":257444,"RR":"<b>Natrah, F.M.I.; Alam, M.I.; Pawar, S.; Harzevili, A.S.; Nevejan, N.; Boon, N.; Sorgeloos, P.; Bossier, P.; Defoirdt, T.</b> (2012). The impact of quorum sensing on the virulence of <i>Aeromonas hydrophila</i> and <i>Aeromonas salmonicida</i> towards burbot (<i>Lota lota</i> L.) larvae. <i>Vet. Microbiol. 159(1-2)</i>: 77-82. <a href=\"https://dx.doi.org/10.1016/j.vetmic.2012.03.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.vetmic.2012.03.014</a>","BEntID":249453,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Vet. Microbiol. 159(1-2)</i>: 77-82. <a href=\"https://dx.doi.org/10.1016/j.vetmic.2012.03.014\" target=\"_blank\">https://dx.doi.org/10.1016/j.vetmic.2012.03.014</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Natrah, F.M.I.; Alam, M.I.; Pawar, S.; Harzevili, A.S.; Nevejan, N.; Boon, N.; Sorgeloos, P.; Bossier, P.; Defoirdt, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Natrah, F.M.I. <i>et al.</i>","Englishabstract":"In this study, the link between quorum sensing in <i>Aeromonas</i> spp. and its virulence towards burbot (<i>Lota lota</i>) was investigated. High mortality occurred in burbot juveniles challenged with <i>Aeromonas salmonicida</i> HN-00, but not in juveniles challenged with <i>Aeromonas hydrophila</i> AH-1N. Meanwhile, both <i>A. hydrophila</i> AH-1N and <i>A. salmonicida</i> HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of <i>A. hydrophila</i> AH-1N towards burbot larvae was further investigated using quorum sensing mutants (<i>N</i>-(butyryl)-l-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule <i>N</i>-butyryl-<span class=\"smallcaps\">l</span>-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both <i>Aeromonas</i> strains. Finally, the freshwater micro-algae <i>Chlorella saccharophila</i> and <i>Chlamydomonas reinhardtii</i>, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of <i>Aeromonas</i> spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The impact of quorum sensing on the virulence of <i>Aeromonas hydrophila</i> and <i>Aeromonas salmonicida</i> towards burbot (<i>Lota lota</i> L.) larvae","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-17 01:32:04.241123","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Quorum sensing; Aeromonas sp.; Acylated homoserine lactone; Quorumsensing inhibitor; Cinnamaldehyde; Micro-alga","OtherDescriptors":null,"Notes":null,"AnaPub":2012,"MonPub":null,"DateUpdate":"2020-06-25","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000308121500010","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.vetmic.2012.03.014"},"refs":null,"anarec":{"AnaID":257444,"PubliDate":2012,"Pagination":"77-82","XtraPublOfAnaID":null,"ISBN":null,"Volume":"159","Issue":"1-2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":122982,"SerRR":"Veterinary Microbiology. 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