{"refrec":{"BRefID":257585,"RR":"<b>Lamoral-Theys, D.; Fattorusso, E.; Mangoni, A.; Perinu, C.; Kiss, R.; Costantino, V.</b> (2011). Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge <i>Pseudoaxinella flava</i> in apoptosis-sensitive and apoptosis-resistant cancer cell lines. <i>J. Nat. Prod. 74(10)</i>: 2299-2303. <a href=\"https://dx.doi.org/10.1021/np2005055\" target=\"_blank\">https://dx.doi.org/10.1021/np2005055</a>","BEntID":249594,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Nat. Prod. 74(10)</i>: 2299-2303. <a href=\"https://dx.doi.org/10.1021/np2005055\" target=\"_blank\">https://dx.doi.org/10.1021/np2005055</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lamoral-Theys, D.; Fattorusso, E.; Mangoni, A.; Perinu, C.; Kiss, R.; Costantino, V.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lamoral-Theys, D. <i>et al.</i>","Englishabstract":"One new (1) and three known (2-4) isonitrile diterpenes, isolated from the Caribbean sponge <i>Pseudoaxinella flava</i>, were assayed in human cancer cell lines in vitro using an MTT colorimetric assay and quantitative videomicroscopy. Compounds 1-4 displayed activity for human PC3 prostate apoptosis-sensitive cancer cell lines. Compounds 3 and 4 demonstrated similar growth inhibitory effects for three apoptosis-sensitive and three apoptosis-resistant cancer cell lines: Quantitative videomicroscopy analysis revealed that compounds 1 and 2 exerted their activity through cytotoxic effects, and compounds 3 and 4 through cytostatic effects. These results identify marine diterpene isonitriles as potential lead compounds for anticancer drug discovery.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Evaluation of the antiproliferative activity of diterpene isonitriles from the sponge <i>Pseudoaxinella flava</i> in apoptosis-sensitive and apoptosis-resistant cancer cell lines","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-25 01:32:15.937650","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2011,"MonPub":null,"DateUpdate":"2020-06-19","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000296206500043","VABBcode":null,"OpenAcc":0,"DOI":"10.1021/np2005055"},"refs":null,"anarec":{"AnaID":257585,"PubliDate":2011,"Pagination":"2299-2303","XtraPublOfAnaID":null,"ISBN":null,"Volume":"74","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43089,"SerRR":"Journal of Natural Products. 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