{"refrec":{"BRefID":257646,"RR":"<b>McCarron, P.; Emteborg, H.; Giddings, S.; Wright, E.; Quilliam, M.</b> (2011). A mussel tissue certified reference material for multiple phycotoxins. Part 3: homogeneity and stability. <i>Anal. Bioanal. Chem. 400(3)</i>: 847-858. <a href=\"https://dx.doi.org/10.1007/s00216-011-4787-8\" target=\"_blank\">https://dx.doi.org/10.1007/s00216-011-4787-8</a>","BEntID":249655,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Anal. Bioanal. Chem. 400(3)</i>: 847-858. <a href=\"https://dx.doi.org/10.1007/s00216-011-4787-8\" target=\"_blank\">https://dx.doi.org/10.1007/s00216-011-4787-8</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"McCarron, P.; Emteborg, H.; Giddings, S.; Wright, E.; Quilliam, M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"McCarron, P. <i>et al.</i>","Englishabstract":"A candidate certified reference material (CRM) for multiple shellfish toxins (domoic acid, okadaic acid and dinophysistoxins, pectenotoxins, yessotoxin, azaspiracids and spirolides) has been prepared as a freeze-dried powder from mussel tissues (<i>Mytilus edulis</i>). Along with the certified values, the most important characteristics for a reference material to be fit-for-purpose are homogeneity and stability. Acceptable between-bottle homogeneity was found for this CRM. Within-bottle homogeneity was assessed using domoic acid, and it was shown that repeated subsampling of the CRM can be performed precisely down to 0.35 g. Both short- and long-term stability studies carried out under isochronous conditions demonstrated excellent stability of the various toxins present in the material. While degradation of some analytes was observed at +60°C in short-term studies, it was determined that shipping at ambient temperature is adequate. No instability was detected in long-term stability studies, and it was shown that the material can be held at +18°C safely for up to 1 year. To guarantee stability of the CRM over its lifetime the stock will be maintained at -20°C. The results of the homogeneity and stability testing show that CRM–FDMT1 is appropriate for its intended use in quality assurance and quality control of shellfish toxin analysis methods.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A mussel tissue certified reference material for multiple phycotoxins. Part 3: homogeneity and stability","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-20 01:32:11.809797","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Shellfish toxins; Phycotoxins; CRM-FDMT1; Stability; Homogeneity; LC-MS;HPLC","OtherDescriptors":null,"Notes":null,"AnaPub":2011,"MonPub":null,"DateUpdate":"2020-06-19","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000289297000028","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s00216-011-4787-8"},"refs":null,"anarec":{"AnaID":257646,"PubliDate":2011,"Pagination":"847-858","XtraPublOfAnaID":null,"ISBN":null,"Volume":"400","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":65810,"SerRR":"Analytical and Bioanalytical Chemistry. Springer: Heidelberg.  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