{"refrec":{"BRefID":257886,"RR":"<b>Sung, Y.; Ashame, M.F.; Chen, S.; MacRae, T.; Sorgeloos, P.; Bossier, P.</b> (2009). Feeding <i>Artemia franciscana</i> (Kellogg) larvae with bacterial heat shock protein, protects from <i>Vibrio campbellii</i> infection. <i>J. Fish Dis. 32(8)</i>: 675-685. <a href=\"https://dx.doi.org/10.1111/j.1365-2761.2009.01046.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1365-2761.2009.01046.x</a>","BEntID":249896,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Fish Dis. 32(8)</i>: 675-685. <a href=\"https://dx.doi.org/10.1111/j.1365-2761.2009.01046.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1365-2761.2009.01046.x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sung, Y.; Ashame, M.F.; Chen, S.; MacRae, T.; Sorgeloos, P.; Bossier, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sung, Y. <i>et al.</i>","Englishabstract":"Among their numerous physiological effects, heat shock proteins (Hsps) are potent immunomodulators, a characteristic reflecting their potential as therapeutic agents and which led to their application in combating infection. As an example, the up-regulation of endogenous Hsp70 in the branchiopod crustacean <i>Artemia franciscana</i> (Kellogg) is concurrent with shielding against bacterial infection. To better understand this protective mechanism, gnotobiotic <i>Artemia</i> were fed with <i>Escherichia coli</i> treated to over-produce different prokaryotic Hsps. This was shown to increase larval resistance to experimental <i>Vibrio campbellii</i> exposure. Immunoprobing of Western blots showed that the enhanced resistance to <i>V. campbellii</i> correlated with DnaK production in <i>E coli</i>. A definitive role for DnaK was then demonstrated by feeding <i>Artemia</i> larvae with transformed bacteria over-producing only this protein, although other Hsps such as DnaJ and grpE also provided tolerance against <i>Vibrio</i> infection. Feeding of bacteria synthesizing selected Hsps is therefore suggested as an alternative to antibiotic use as a means of enhancing resistance of <i>Artemia</i> larvae to bacterial infection, which may have potential applications in aquaculture.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Feeding <i>Artemia franciscana</i> (Kellogg) larvae with bacterial heat shock protein, protects from <i>Vibrio campbellii</i> infection","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-22 01:31:52.353858","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Artemia; DnaK; heat shock proteins; Vibrio","OtherDescriptors":null,"Notes":null,"AnaPub":2009,"MonPub":null,"DateUpdate":"2020-06-19","DateCreate":"2016-05-29","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000268057400004","VABBcode":null,"OpenAcc":0,"DOI":"10.1111/j.1365-2761.2009.01046.x"},"refs":null,"anarec":{"AnaID":257886,"PubliDate":2009,"Pagination":"675-685","XtraPublOfAnaID":null,"ISBN":null,"Volume":"32","Issue":"8","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44476,"SerRR":"Journal of Fish Diseases. 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