{"refrec":{"BRefID":259213,"RR":"<b>Li, H.; Xu, W.; Zhang, N.; Shao, C.; Zhu, Y.; Dong, Z.; Wang, N.; Jia, X.; Xu, H.; Chen, S.</b> (2016). Two Figla homologues have disparate functions during sex differentiation in half-smooth tongue sole (<i>Cynoglossus semilaevis</i>). <i>NPG Scientific Reports 6(28219)</i>: 10 pp. <a href=\"http://dx.doi.org/10.1038/srep28219\" target=\"_blank\">http://dx.doi.org/10.1038/srep28219</a>","BEntID":251220,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 6(28219)</i>: 10 pp. <a href=\"http://dx.doi.org/10.1038/srep28219\" target=\"_blank\">http://dx.doi.org/10.1038/srep28219</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Li, H.; Xu, W.; Zhang, N.; Shao, C.; Zhu, Y.; Dong, Z.; Wang, N.; Jia, X.; Xu, H.; Chen, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Li, H. <i>et al.</i>","Englishabstract":"Figla is a germ-cell-specific transcription factor associated with ovary development and differentiation. In vertebrates, one transcriptional form of Figla is commonly found. However, besides the common form of this gene (named Figla_tv1), a new transcriptional form (named Figla_tv2) was identified in half-smooth tongue sole (Cynoglossus semilaevis). The full-length cDNA of Figla_tv1 was 1057 bp long with a 591-bp open reading frame encoding a predicted 196 amino acid protein, while Figla_tv2 encoded a 125 amino acid protein. Figla_tv1 and Figla_tv2 expression in various tissues was detected by qRT-PCR. Figla_tv1 was expressed mainly in ovary, skin and liver, while Figla_tv2 was expressed in all examined tissues. In the gonads, Figla_tv1 was expressed in ovary, while Figla_tv2 was predominately expressed in testis of pseudomales. Further, in situ hybridization located Figla_tv1 only in oocytes and Figla_tv2 mainly in germ cells of pseudomale testis. After knocking down Figla_tv2 in a pseudomale testis cell line, the expression of two steroid hormone-encoding genes, StAR and P450scc, was significantly upregulated (P < 0.05). Our findings suggest that Figla_tv1 has a conserved function in folliculogenesis, as in other vertebrates, and that Figla_tv2 may have a role in the spermatogenesis of pseudomales by regulating the synthesis and metabolism of steroid hormones.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Two Figla homologues have disparate functions during sex differentiation in half-smooth tongue sole (<i>Cynoglossus semilaevis</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-15 01:32:53.503696","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2016,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2016-06-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000377997000001","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/srep28219"},"refs":null,"anarec":{"AnaID":259213,"PubliDate":2016,"Pagination":"10 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"6","Issue":"28219","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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