{"refrec":{"BRefID":260765,"RR":"<b>Metzger, M.J.; Villalba, A.; Carballal, M.J.; Iglesias, D.; Sherry, J.; Reinisch, C.; Muttray, A.F.; Baldwin, S.A.; Goff, S.P.</b> (2016). Widespread transmission of independent cancer lineages within multiple bivalve species. <i>Nature (Lond.) 534(7609)</i>: 705-709. <a href=\"http://dx.doi.org/10.1038/nature18599\" target=\"_blank\">http://dx.doi.org/10.1038/nature18599</a>","BEntID":252783,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature (Lond.) 534(7609)</i>: 705-709. <a href=\"http://dx.doi.org/10.1038/nature18599\" target=\"_blank\">http://dx.doi.org/10.1038/nature18599</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Metzger, M.J.; Villalba, A.; Carballal, M.J.; Iglesias, D.; Sherry, J.; Reinisch, C.; Muttray, A.F.; Baldwin, S.A.; Goff, S.P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Metzger, M.J. <i>et al.</i>","Englishabstract":"Most cancers arise from oncogenic changes in the genomes of somatic cells, and while the cells may migrate by metastasis, they remain within that single individual. Natural transmission of cancer cells from one individual to another has been observed in two distinct cases in mammals (Tasmanian devils and dogs), but these are generally considered to be rare exceptions in nature. The discovery of transmissible cancer in soft-shell clams (<i>Mya arenaria</i> suggested that this phenomenon might be more widespread. Here we analyse disseminated neoplasia in mussels (<i>Mytilus trossulus</i>), cockles (<i>Cerastoderma edule</i>), and golden carpet shell clams (<i>Polititapes aureus</i>) and find that neoplasias in all three species are attributable to independent transmissible cancer lineages. In mussels and cockles, the cancer lineages are derived from their respective host species; however, unexpectedly, cancer cells in <i>P. aureus</i> are all derived from <i>Venerupis corrugata</i>, a different species living in the same geographical area. No cases of disseminated neoplasia have thus far been found in <i>V. corrugata</i> from the same region. These findings show that transmission of cancer cells in the marine environment is common in multiple species, that it has originated many times, and that while most transmissible cancers are found spreading within the species of origin, cross-species transmission of cancer cells can occur.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Widespread transmission of independent cancer lineages within multiple bivalve species","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-14 01:31:36.393080","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Neoplasias; Cancer lineages ","OtherDescriptors":null,"Notes":null,"AnaPub":2016,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2016-07-28","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000378676000041","VABBcode":null,"OpenAcc":0,"DOI":"10.1038/nature18599"},"refs":null,"anarec":{"AnaID":260765,"PubliDate":2016,"Pagination":"705-709","XtraPublOfAnaID":null,"ISBN":null,"Volume":"534","Issue":"7609","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43431,"SerRR":"Nature: International Weekly Journal of Science. Nature Publishing Group: London.  ISSN 0028-0836; e-ISSN 1476-4687","StandardTitleSer":"Nature: International Weekly Journal of Science","ISSN":"0028-0836","AbbrevSer":"Nature (Lond.)","StandardTitleMon":null,"StartPage":705,"Pages":5,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Metzger","Firstname":"Michael","Initials":"M.J.","Affiliation":"Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302926,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Villalba","Firstname":"Antonio","Initials":"A.","Affiliation":"Conselleria Mar, Ctr Invest Marinas, Xunta De Galicia 36620, Vilanova De Aro, Spain.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302927,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Carballal","Firstname":"María","Initials":"M.J.","Affiliation":"Conselleria Mar, Ctr Invest Marinas, Xunta De Galicia 36620, Vilanova De Aro, Spain.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302928,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Iglesias","Firstname":"David","Initials":"D.","Affiliation":"Conselleria Mar, Ctr Invest Marinas, Xunta De Galicia 36620, Vilanova De Aro, Spain.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302929,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sherry","Firstname":"James","Initials":"J.","Affiliation":"Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302930,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Reinisch","Firstname":"Carol","Initials":"C.","Affiliation":"Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302931,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Muttray","Firstname":"Annette","Initials":"A.F.","Affiliation":"Univ British Columbia, Chem & Biol Engn, Vancouver, BC V6T 1Z3, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302932,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Baldwin","Firstname":"Susan","Initials":"S.A.","Affiliation":"Univ British Columbia, Chem & Biol Engn, Vancouver, BC V6T 1Z3, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302933,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Goff","Firstname":"Stephen","Initials":"S.P.","Affiliation":"Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA.","Discriminator":null,"CorporateFlag":0,"BEntID":252783,"AutID":302934,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":294039,"LibID":36,"BRefID":260765,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"294039","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Marine environment","ThestID":4999,"Acronym":"ASFA","ThesTermPath":"Environments > Aquatic environment > Marine environment"}],"thestermsASFA":[{"ThesaurusTerm":"Marine environment"}],"taxtermsASFA":[{"TaxTerm":"Cerastoderma edule"},{"TaxTerm":"Mya arenaria"},{"TaxTerm":"Mytilus trossulus"},{"TaxTerm":"Polititapes aureus"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":252783,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":252783,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"http://dx.doi.org/10.1038/nature18599","externalID":"10.1038/nature18599","URLTypeCode":"DOI","URLID":49947,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Marine environment","ThestID":4999,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxterms":[{"TaxTerm":"Cerastoderma edule [Common cockle]","AphiaID":138998,"TaxtID":22819},{"TaxTerm":"Mya arenaria","AphiaID":140430,"TaxtID":40681},{"TaxTerm":"Mytilus trossulus [foolish mussel]","AphiaID":140482,"TaxtID":35886},{"TaxTerm":"Polititapes aureus","AphiaID":246150,"TaxtID":42122}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Marine environment","DutchTerm":"Marien milieu","ThestID":4999,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxtermsFRIS":[{"TaxTerm":"Cerastoderma edule","DutchTerm":"Gewone kokkel","AphiaID":138998,"TaxtID":22819},{"TaxTerm":"Mya arenaria","DutchTerm":null,"AphiaID":140430,"TaxtID":40681},{"TaxTerm":"Mytilus trossulus","DutchTerm":null,"AphiaID":140482,"TaxtID":35886},{"TaxTerm":"Polititapes aureus","DutchTerm":null,"AphiaID":246150,"TaxtID":42122}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2016-07-28 10:09:28.867000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-02-13 19:34:46.407000","timezone_type":3,"timezone":"Europe/Brussels"}}}