{"refrec":{"BRefID":261767,"RR":"Vercauteren, K.; Blust, R. (1999). Uptake of cadmium and zinc by the mussel Mytilus edulis and inhibition by calcium channel and metabolic blockers. Mar. Biol. (Berl.) 135(4): 615-626. https://dx.doi.org/10.1007/s002270050662","BEntID":253785,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". Mar. Biol. (Berl.) 135(4): 615-626. https://dx.doi.org/10.1007/s002270050662","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vercauteren, K.; Blust, R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vercauteren, K.; Blust, R.","Englishabstract":"The mussel Mytilus edulis is extensively used to monitor metal contamination of estuarine and marine systems. Nonetheless, the mechanisms of metal uptake are poorly understood. To characterise the systems involved in cadmium and zinc uptake, the interaction between the two metals and the effects of different calcium channel blockers (diltiazem, nifedipine, verapamil) and inhibitors of active transport and metabolism (ouabain, sodium cyanide, 2,4 dinitrophenol) on the uptake of calcium, cadmium and zinc in Mytilus edulis have been studied. To separate direct from indirect effects of the inhibitors on metal uptake, their influence on the physiological condition of the mussels was also investigated. This was done by measuring clearance, respiration and excretion rates under the different exposure regimes and determining the scope for growth as an integrative index for physiological condition. The study has shown that the uptake of cadmium and zinc by Mytilus edulis can be modulated by calcium channel blockers and other inhibitors. The inhibitors also influenced physiological condition, but a significant correlation with the effects on metal uptake did not exist in most cases. Cadmium and zinc also inhibit each other's uptake, but the type of inhibition is not yet clear. The effects of the inhibitors on cadmium and zinc uptake are very different from the effects on calcium uptake, indicating that cadmium and zinc are preferentially taken up through other gateways. Overall, a significant degree of linear association is found between the effects of the inhibitors on the uptake of cadmium and zinc, suggesting common uptake routes. In addition, the effects of the calcium channel antagonist on the uptake of the metal ions are organ dependent, indicating that other types of channels are involved in the uptake of the metal ions in the gills and digestive system.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Uptake of cadmium and zinc by the mussel Mytilus edulis and inhibition by calcium channel and metabolic blockers","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-02 01:31:36.051437","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1999,"MonPub":null,"DateUpdate":"2022-04-15","DateCreate":"2016-10-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000084638000005","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s002270050662"},"refs":null,"anarec":{"AnaID":261767,"PubliDate":1999,"Pagination":"615-626","XtraPublOfAnaID":null,"ISBN":null,"Volume":"135","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43352,"SerRR":"Marine Biology: International Journal on Life in Oceans and Coastal Waters. Springer: Heidelberg; Berlin. ISSN 0025-3162; e-ISSN 1432-1793","StandardTitleSer":"Marine Biology: International Journal on Life in Oceans and Coastal Waters","ISSN":"0025-3162","AbbrevSer":"Mar. Biol. (Berl.)","StandardTitleMon":null,"StartPage":615,"Pages":12,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Vercauteren","Firstname":"Kathleen","Initials":"K.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253785,"AutID":242448,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":2622,"InsID":null},{"AutName":"Blust","Firstname":"Ronny","Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253785,"AutID":1984,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":201,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":375779,"LibID":36,"BRefID":261767,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"375779","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"
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