{"refrec":{"BRefID":261773,"RR":"<b>Le, M.T.; Vanderheyden, P.M.L.; De Backer, J.-P.; Vanquelin, G.; Vanden Broeck, J.</b> (1999). High affinity displacement of [<sup>3</sup>H]NPY binding to the crude venom of <i>Conus anemone</i> by insect neuropeptides. <i>Biochem. Biophys. Res. Commun. 262(1)</i>: 180-186. <a href=\"https://dx.doi.org/10.1006/bbrc.1999.1177\" target=\"_blank\">https://dx.doi.org/10.1006/bbrc.1999.1177</a>","BEntID":253791,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Biochem. Biophys. Res. Commun. 262(1)</i>: 180-186. <a href=\"https://dx.doi.org/10.1006/bbrc.1999.1177\" target=\"_blank\">https://dx.doi.org/10.1006/bbrc.1999.1177</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Le, M.T.; Vanderheyden, P.M.L.; De Backer, J.-P.; Vanquelin, G.; Vanden Broeck, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Le, M.T. <i>et al.</i>","Englishabstract":"The venom from <i>Conus anemone</i> contains a protein, named ANPY toxin, which displayed high affinity (IC<sub>50</sub> in nanomolar range) to neuropeptide Y (NPY), [Leu<sup>31</sup>, Pro<sup>34</sup>]NPY, peptide YY, pancreatic polypeptide, the Y<sub>1</sub> antagonist 1229U91, and C-terminal NPY fragments. N-terminal fragments and the free acid form of NPY did not bind to ANPY. The truncated NPY fragments displayed very low affinity to Y<sub>1</sub> receptors and partially inhibited [<sup>3</sup>H]NPY binding to anti-NPY antiserum. Several insect neuropeptides, the sequences of which related to the C-terminal fragments of NPY, were observed to bind with similar affinity or even 20 times higher (Lom-MS and Scg-NPF) affinity than NPY. In contrast, no significant binding of these insect peptides was observed for Y<sub>1</sub> receptors and anti-NPY antiserum. Therefore, ANPY can be viewed as an acceptor that binds with very high affinity to a broad spectrum of vertebrate and invertebrate neuropeptides that share a similar C-terminal amino acid sequence.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"High affinity displacement of [<sup>3</sup>H]NPY binding to the crude venom of <i>Conus anemone</i> by insect neuropeptides","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-15 01:32:56.191433","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Conus anemone; insect peptide; NPY; Y-1 receptors; anti-NPY antibodies","OtherDescriptors":null,"Notes":null,"AnaPub":1999,"MonPub":null,"DateUpdate":"2022-04-15","DateCreate":"2016-10-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000082261000032","VABBcode":null,"OpenAcc":0,"DOI":"10.1006/bbrc.1999.1177"},"refs":null,"anarec":{"AnaID":261773,"PubliDate":1999,"Pagination":"180-186","XtraPublOfAnaID":null,"ISBN":null,"Volume":"262","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42249,"SerRR":"Biochemical and Biophysical Research Communications. ACADEMIC PRESS INC ELSEVIER SCIENCE: San Diego etc..  ISSN 0006-291X; e-ISSN 1090-2104","StandardTitleSer":"Biochemical and Biophysical Research Communications","ISSN":"0006-291X","AbbrevSer":"Biochem. Biophys. Res. Commun.","StandardTitleMon":null,"StartPage":180,"Pages":7,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Le","Firstname":"Minh Tam","Initials":"M.T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253791,"AutID":238775,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vanderheyden","Firstname":"Patrick","Initials":"P.M.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253791,"AutID":242477,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"De Backer","Firstname":"Jean-Paul","Initials":"J.-P.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253791,"AutID":242478,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vanquelin","Firstname":"Georges","Initials":"G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253791,"AutID":238778,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vanden Broeck","Firstname":"Jozef","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":253791,"AutID":238779,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":375688,"LibID":36,"BRefID":261773,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"375688","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"ACADEMIC PRESS INC ELSEVIER SCIENCE","City":"San Diego etc."}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Conus anemone"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":253791,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":253791,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1006/bbrc.1999.1177","externalID":"10.1006/bbrc.1999.1177","URLTypeCode":"DOI","URLID":50497,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Conus anemone","AphiaID":426319,"TaxtID":42576}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Conus anemone","DutchTerm":null,"AphiaID":426319,"TaxtID":42576}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2016-10-03 20:16:18.820000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2022-04-15 08:15:31.570000","timezone_type":3,"timezone":"Europe/Brussels"}}}