{"refrec":{"BRefID":262099,"RR":"<b>Vallarino, M.; Fasolo, A.; Ottonello, I.; Perroteau, I.; Tonon, M.C.; Vandesande, F.; Vaudry, H.</b> (1989). Localization of corticotropin-releasing hormone (CRF)-like immunoreactivity in the central nervous system of the elasmobranch fish, <i>Scyliorhinus canicula</i>. <i>Cell Tissue Res. 258(3)</i>: 541-546. <a href=\"https://dx.doi.org/10.1007/BF00218865\" target=\"_blank\">https://dx.doi.org/10.1007/BF00218865</a>","BEntID":254118,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Cell Tissue Res. 258(3)</i>: 541-546. <a href=\"https://dx.doi.org/10.1007/BF00218865\" target=\"_blank\">https://dx.doi.org/10.1007/BF00218865</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vallarino, M.; Fasolo, A.; Ottonello, I.; Perroteau, I.; Tonon, M.C.; Vandesande, F.; Vaudry, H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vallarino, M. <i>et al.</i>","Englishabstract":"The occurrence and localization of immunoreactive corticotropin-releasing factor (CRF) in the brain and pituitary of the elasmobranch fish <i>Scyliorhinus canicula</i>, were studied by means of specific radioimmunoassay and immunohistochemistry using the indirect immunofluorescence method. Brain and pituitary extracts showed a good cross-reactivity with the ovine CRF antiserum, but serial dilutions of tissue samples did not completely parallel the standard curve. Relatively high concentrations of CRF-like material were found within the pituitary, diencephalon, and telencephalon. CRF-like immunoreactive perikarya were observed in the preoptic nucleus and in the nucleus lateralis tuberis. Numerous immunoreactive cells appeared to be of the CSF-contacting type. CRF-like immunopositive fibers were seen to run through the hypothalamus within the ventro-medial floor of the infundibular region. A dense plexus of immunoreactive nerve endings terminated in the median eminence and the neurointermediate lobe of the pituitary. These results indicate that a neurosecretory system containing CRF-like immunoreactivity exists in the brain of elasmobranchs, a group of vertebrates which has diverged early from the evolutionary line leading to mammals. In addition, our data support the notion that a CRF-like molecule is involved in the regulation of corticotropic and melanotropic cell activity in this primitive species of fish.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Localization of corticotropin-releasing hormone (CRF)-like immunoreactivity in the central nervous system of the elasmobranch fish, <i>Scyliorhinus canicula</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-08 01:31:08.471111","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1989,"MonPub":null,"DateUpdate":"2022-04-13","DateCreate":"2016-10-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1989CC25600008","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/BF00218865"},"refs":null,"anarec":{"AnaID":262099,"PubliDate":1989,"Pagination":"541-546","XtraPublOfAnaID":null,"ISBN":null,"Volume":"258","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42554,"SerRR":"Cell and Tissue Research. 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