{"refrec":{"BRefID":280700,"RR":"<b>Genta-Jouve, G.; Ioannou, E.; Mathieu, V.; Bruyère, C.; Lefranc, F.; Thomas, O.P.; Kiss, R.; Roussis, V.</b> (2012). Determination of the absolute configuration and evaluation of the in vitro antitumor activity of dilospirane B. <i>Phytochemistry Letters 5(4)</i>: 747-751. <a href=\"https://dx.doi.org/10.1016/j.phytol.2012.08.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.phytol.2012.08.005</a>","BEntID":272719,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Phytochemistry Letters 5(4)</i>: 747-751. <a href=\"https://dx.doi.org/10.1016/j.phytol.2012.08.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.phytol.2012.08.005</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Genta-Jouve, G.; Ioannou, E.; Mathieu, V.; Bruyère, C.; Lefranc, F.; Thomas, O.P.; Kiss, R.; Roussis, V.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Genta-Jouve, G. <i>et al.</i>","Englishabstract":"The absolute configuration of dilospirane B (1), a diterpene featuring a novel carbon framework recently isolated from the brown alga <i>Dilophus spiralis</i>, was established on the basis of theoretical calculations of its electronic circular dichroism spectra applying the time-dependent density functional theory method. Metabolite 1, evaluated for its in vitro antitumor activity against six human cancer cell lines displaying various levels of sensitivity to pro-apoptotic stimuli, exhibited growth inhibitory activity with a mean IC<sub>50</sub> value of 66 μM. Quantitative videomicroscopy analyses indicated that 1 initially displays cytostatic effects which later become cytotoxic.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Determination of the absolute configuration and evaluation of the in vitro antitumor activity of dilospirane B","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Dilospirane B; Absolute configuration; ECD; Antitumor activity","OtherDescriptors":null,"Notes":null,"AnaPub":2012,"MonPub":null,"DateUpdate":"2022-07-08","DateCreate":"2016-10-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000311337300014","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.phytol.2012.08.005"},"refs":null,"anarec":{"AnaID":280700,"PubliDate":2012,"Pagination":"747-751","XtraPublOfAnaID":null,"ISBN":null,"Volume":"5","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":276420,"SerRR":"Phytochemistry Letters. ELSEVIER SCIENCE BV: Amsterdam.  ISSN 1874-3900; e-ISSN 1876-7486","StandardTitleSer":"Phytochemistry Letters","ISSN":"1874-3900","AbbrevSer":null,"StandardTitleMon":null,"StartPage":747,"Pages":5,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Genta-Jouve","Firstname":"Grégory","Initials":"G.","Affiliation":"Univ Nice Sophia Antipolis, Fac Sci, Team PCRE, Inst Chim Nice,CNRS,UMR 7272, F-06108 Nice 02, France.","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240623,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ioannou","Firstname":"Efstathia","Initials":"E.","Affiliation":"Univ Athens, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece.","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240624,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Mathieu","Firstname":"Véronique","Initials":"V.","Affiliation":"Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240625,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":34886,"InsID":null},{"AutName":"Bruyère","Firstname":"Céline","Initials":"C.","Affiliation":"Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240626,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Lefranc","Firstname":"Florence","Initials":"F.","Affiliation":"Service de Neurochirurgie, Hôpital Erasme, Université Libre de Bruxelles","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240627,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Thomas","Firstname":"Olivier","Initials":"O.P.","Affiliation":"Univ Nice Sophia Antipolis, Fac Sci, Team PCRE, Inst Chim Nice,CNRS,UMR 7272, F-06108 Nice 02, France.","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240628,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Kiss","Firstname":"Robert","Initials":"R.","Affiliation":"Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240629,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":34845,"InsID":null},{"AutName":"Roussis","Firstname":"Vassilios","Initials":"V.","Affiliation":"Univ Athens, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece.","Discriminator":null,"CorporateFlag":0,"BEntID":272719,"AutID":240630,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":378958,"LibID":36,"BRefID":280700,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"378958","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"ELSEVIER SCIENCE BV","City":"Amsterdam"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":272719,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":272719,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.phytol.2012.08.005","externalID":"10.1016/j.phytol.2012.08.005","URLTypeCode":"DOI","URLID":51067,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2016-10-09 21:07:26.660000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"VLIZ2000\\elid","updSesDate":{"date":"2022-07-08 09:21:10.513000","timezone_type":3,"timezone":"Europe/Brussels"}}}
