{"refrec":{"BRefID":280754,"RR":"<b>Kumar, S.S.; Kumar, Y.; Khan, M.S.Y.; Anbu, J.; De Clercq, E.</b> (2011). Antihistaminic and antiviral activities of steroids of <i>Turbinaria conoides</i>. <i>Natural Product Research 25(7)</i>: 723-729. <a href=\"http://dx.doi.org/10.1080/14786411003781515\" target=\"_blank\">dx.doi.org/10.1080/14786411003781515</a>","BEntID":272773,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Nat. Prod. Res. 25(7)</i>: 723-729. <a href=\"https://dx.doi.org/10.1080/14786411003781515\" target=\"_blank\">https://dx.doi.org/10.1080/14786411003781515</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kumar, S.S.; Kumar, Y.; Khan, M.S.Y.; Anbu, J.; De Clercq, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kumar, S.S. <i>et al.</i>","Englishabstract":"The steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (A) and 14,15,18,20-diepoxyturbinarin (B) were isolated from the cyclohexane extract of brown alga, <i>Turbinaria conoides</i> (J. Agardh) Kutzing, and have been reported for their antimicrobial activity by us. In this study, the isolated compounds were evaluated for comprehensive antihistaminic, antiviral and cytotoxicity screening. The antihistaminic study was performed using <i>in vitro</i> standard animal models. Evaluation of the potency (EC<sub>50</sub>), affinity (pA<sub>2</sub>) and the maximal response (<i>E</i> <sub>max</sub>) of the histamine alone and in the presence of the compounds were determined. Antiviral activity and cytotoxicity were performed in Crandell-Rees feline kidney (CRFK) cells by a colorimetric formazan-based MTS assay. No significant antiviral activity or cytotoxicity were observed for the compounds in the CRFK cells. Compound A inhibited the histamine-induced concentration at 20 µg mL<sup>−1</sup>(<i>p</i><0.05). The most significant inhibition (97%) was observed for compound B (<i>p</i><0.01) at the same concentration, which was comparable to that of the positive control chlorpheniramine maleate (10 µg mL<sup>−1</sup>). This potentiality suggests that 14,15,18,20-diepoxyturbinarin (B) can be developed as a new lead antihistaminic agent.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Antihistaminic and antiviral activities of steroids of <i>Turbinaria conoides</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Turbinaria conoides; antihistaminic; antiviral; cytotoxicity; steroid;3; 6; 17-trihydroxy-stigmasta-4; 7; 24(28)-triene; 14; 15; 18;20-diepoxyturbinarin","OtherDescriptors":null,"Notes":null,"AnaPub":2011,"MonPub":null,"DateUpdate":"2016-10-20","DateCreate":"2016-10-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000289258300007","VABBcode":null,"OpenAcc":0,"DOI":"10.1080/14786411003781515"},"refs":null,"anarec":{"AnaID":280754,"PubliDate":2011,"Pagination":"723-729","XtraPublOfAnaID":null,"ISBN":null,"Volume":"25","Issue":"7","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":275170,"SerRR":"Natural Product Research. Taylor & Francis: Abingdon.  ISSN 1478-6419; e-ISSN 1478-6427","StandardTitleSer":"Natural Product Research","ISSN":"1478-6419","AbbrevSer":"Nat. Prod. Res.","StandardTitleMon":null,"StartPage":723,"Pages":7,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Kumar","Firstname":"S. Sadish","Initials":"S.S.","Affiliation":"ITS Paramed Coll Pharm, Dept Pharmaceut Chem, Ghaziabad, Uttar Pradesh, India.","Discriminator":null,"CorporateFlag":0,"BEntID":272773,"AutID":241023,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Kumar","Firstname":null,"Initials":"Y.","Affiliation":"ITS Paramed Coll Pharm, Dept Pharmaceut Chem, Ghaziabad, Uttar Pradesh, India.","Discriminator":null,"CorporateFlag":0,"BEntID":272773,"AutID":241024,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Khan","Firstname":null,"Initials":"M.S.Y.","Affiliation":"Jamia Hamdard, Dept Pharmaceut Chem, New Delhi, India.","Discriminator":null,"CorporateFlag":0,"BEntID":272773,"AutID":241025,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Anbu","Firstname":null,"Initials":"J.","Affiliation":"Vels Coll Pharm, Dept Pharmacol, Madras 600117, Tamil Nadu, India.","Discriminator":null,"CorporateFlag":0,"BEntID":272773,"AutID":241026,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"De Clercq","Firstname":"Erik","Initials":"E.","Affiliation":"Rega Institute for Medical Research, Katholieke Universiteit Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":272773,"AutID":241027,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"Katholieke Universiteit Leuven; Rega-instituut","ORCID":null,"PersID":412,"InsID":1567}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":375896,"LibID":36,"BRefID":280754,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"375896","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Taylor & Francis","City":"Abingdon"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Turbinaria conoides"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":272773,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":272773,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1080/14786411003781515","externalID":"10.1080/14786411003781515","URLTypeCode":"DOI","URLID":51115,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Turbinaria conoides","AphiaID":221476,"TaxtID":42844}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Turbinaria conoides","DutchTerm":null,"AphiaID":221476,"TaxtID":42844}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2016-10-09 21:07:26.660000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2016-10-20 09:14:14.600000","timezone_type":3,"timezone":"Europe/Brussels"}}}