{"refrec":{"BRefID":281069,"RR":"<b>Le, M.T.; Vanderheyden, P.M.L.; Baggerman, G.; Vanden Broeck, J.; Vauquelin, G.</b> (2002). Formation of angiotensin-(1-7) from angiotensin II by the venom of <i>Conus geographus</i>. <i>Regulatory Peptides 105(2)</i>: 101-108. <a href=\"https://dx.doi.org/10.1016/S0167-0115(02)00005-8\" target=\"_blank\">https://dx.doi.org/10.1016/S0167-0115(02)00005-8</a>","BEntID":273088,"PublicFlag":1,"CheckedFlag":1,"wosflag":0,"vabbflag":1,"RefStringPartII":". <i>Regulatory Peptides 105(2)</i>: 101-108. <a href=\"https://dx.doi.org/10.1016/S0167-0115(02)00005-8\" target=\"_blank\">https://dx.doi.org/10.1016/S0167-0115(02)00005-8</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Le, M.T.; Vanderheyden, P.M.L.; Baggerman, G.; Vanden Broeck, J.; Vauquelin, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Le, M.T. <i>et al.</i>","Englishabstract":"The binding of [<sup>3</sup>H]angiotensin II to AT<sub>1</sub> receptors on Chinese Hamster Ovary cells expressing the human AT<sub>1</sub> receptor (CHO-AT<sub>1</sub> cells) is potently inhibited by venoms of the marine snails <i>Conus geographus</i> and <i>C. betulinus</i>. On the other hand, the binding of the nonpeptide AT<sub>1</sub> receptor-selective antagonist [<sup>3</sup>H]candesartan is not affected but competition binding curves of angiotensin II and the peptide antagonist [Sar<sup>1</sup>,Ile<sup>8</sup>]angiotensin II (sarile) are shifted to the right. These effects resulted from the breakdown of angiotensin II into smaller fragments that do not bind to the AT<sub>1</sub> receptor. In this context, angiotensin-(1–7) is the most prominent fragment and angiotensin-(1–4) and angiotensin-(1–5) are also formed but to a lesser extent. The molecular weight of the involved peptidases exceeds 50 kDa, as determined by gel chromatography and ultrafitration.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Formation of angiotensin-(1-7) from angiotensin II by the venom of <i>Conus geographus</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"angiotensin II; CHO-AT(1) cells; Conus geographus; radioligand binding;mass spectrometry","OtherDescriptors":null,"Notes":null,"AnaPub":2002,"MonPub":null,"DateUpdate":"2022-07-13","DateCreate":"2016-10-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000174730600004","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/S0167-0115(02)00005-8"},"refs":null,"anarec":{"AnaID":281069,"PubliDate":2002,"Pagination":"101-108","XtraPublOfAnaID":null,"ISBN":null,"Volume":"105","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":281718,"SerRR":"Regulatory Peptides. 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