{"refrec":{"BRefID":281074,"RR":"<b>Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kühn, E.R.; Darras, V.M.</b> (2002). Thyroid hormone deiodinases during embryonic development of the saltwater crocodile (<i>Crocodylus porosus</i>). <i>Gen. Comp. Endocrinol. 126(2)</i>: 153-164. <a href=\"https://dx.doi.org/10.1006/gcen.2002.7786\" target=\"_blank\">https://dx.doi.org/10.1006/gcen.2002.7786</a>","BEntID":273093,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Gen. Comp. Endocrinol. 126(2)</i>: 153-164. <a href=\"https://dx.doi.org/10.1006/gcen.2002.7786\" target=\"_blank\">https://dx.doi.org/10.1006/gcen.2002.7786</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kühn, E.R.; Darras, V.M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Shepherdley, C.A. <i>et al.</i>","Englishabstract":"All tissues of the embryonic saltwater crocodile (<i>Crocodylus porosus</i>) gradually increased in weight during development except for lung tissue, which had a peak weight of 1.09 g at day 67, thereafter decreasing in weight. The brain was a relatively large organ. Deiodinase activities in liver, kidney, lung, heart, gut, and brain from day 29 to day 77 of development of the saltwater crocodile were investigated. High-<i>K<sub>m</sub></i> reverse triiodothyronine (rT<sub>3</sub>) outer ring deiodination (ORD) activity was present in all tissues except the brain. Activity ranged from 559 ± 51.3 pmol rT<sub>3</sub> deiodinated/mg protein/min in the liver at day 77 to below 10 pmol rT<sub>3</sub> deiodinated/mg protein/min in gut, lung, and heart tissue. rT<sub>3</sub> ORD increased during development in the liver and kidney but decreased in the gut and lung. Activity in the heart was very low (less than 2 pmol rT<sub>3</sub> deiodinated/mg protein/min) and did not change during development. Low-<i>K<sub>m</sub></i> thyroxine (T<sub>4</sub>) ORD in liver and kidney tissue had peaks of activity around day 49 of incubation (0.52 and 0.09 fmol T<sub>4</sub> deiodinated/mg protein/min, respectively). After day 49, T<sub>4</sub> ORD activity in these tissues decreased. T<sub>4</sub> ORD activity in gut, lung, and heart was very low (less than 0.04 fmol T<sub>4</sub> deiodinated/mg protein/min), with activity in lung increasing slightly during the rest of development. T<sub>4</sub> ORD activity in the brain increased toward day 77 (0.14 ± 0.03 fmol T<sub>4</sub> deiodinated/mg protein/min), illustrating its importance in local triiodothyronine (T<sub>3</sub>) production during brain development. T<sub>3</sub> inner ring deiodination activity was present only in the embryonic liver and peaked at day 49 (10.1 fmol T<sub>3</sub> deiodinated/mg protein/min), after which activity decreased.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Thyroid hormone deiodinases during embryonic development of the saltwater crocodile (<i>Crocodylus porosus</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-05 01:31:07.486655","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"inner ring deiodination; outer ring deiodination; thyroid hormones;development; tissue distribution; saltwater crocodile","OtherDescriptors":null,"Notes":null,"AnaPub":2002,"MonPub":null,"DateUpdate":"2022-04-15","DateCreate":"2016-10-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000175611900005","VABBcode":null,"OpenAcc":0,"DOI":"10.1006/gcen.2002.7786"},"refs":null,"anarec":{"AnaID":281074,"PubliDate":2002,"Pagination":"153-164","XtraPublOfAnaID":null,"ISBN":null,"Volume":"126","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42729,"SerRR":"General and Comparative Endocrinology. 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