{"refrec":{"BRefID":281207,"RR":"<b>Casas, L.; Saborido-Rey, F.; Ryu, T.; Michell, C.; Ravasi, T.; Irigoien, X.</b> (2016). Sex change in clownfish: molecular insights from transcriptome analysis. <i>NPG Scientific Reports 6(35461)</i>: 19 pp. <a href=\"http://dx.doi.org/10.1038/srep35461\" target=\"_blank\">http://dx.doi.org/10.1038/srep35461</a>","BEntID":273226,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 6(35461)</i>: 19 pp. <a href=\"http://dx.doi.org/10.1038/srep35461\" target=\"_blank\">http://dx.doi.org/10.1038/srep35461</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Casas, L.; Saborido-Rey, F.; Ryu, T.; Michell, C.; Ravasi, T.; Irigoien, X.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Casas, L. <i>et al.</i>","Englishabstract":"Sequential hermaphroditism is a unique reproductive strategy among teleosts that is displayed mainly in fish species living in the coral reef environment. The reproductive biology of hermaphrodites has long been intriguing; however, very little is known about the molecular pathways underlying their sex change. Here, we provide the first de novo transcriptome analyses of a hermaphrodite teleost´s undergoing sex change in its natural environment. Our study has examined relative gene expression across multiple groups—rather than just two contrasting conditions— and has allowed us to explore the differential expression patterns throughout the whole process. Our analysis has highlighted the rapid and complex genomic response of the brain associated with sex change, which is subsequently transmitted to the gonads, identifying a large number of candidate genes, some well-known and some novel, involved in the process. The present study provides strong evidence of the importance of the sex steroidogenic machinery during sex change in clownfish, with the aromatase gene playing a central role, both in the brain and the gonad. This work constitutes the first genome-wide study in a social sex-changing species and provides insights into the genetic mechanism governing social sex change and gonadal restructuring in protandrous hermaphrodites.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Sex change in clownfish: molecular insights from transcriptome analysis","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-15 01:32:57.488424","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2016,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2016-10-18","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000385457700001","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/srep35461"},"refs":null,"anarec":{"AnaID":281207,"PubliDate":2016,"Pagination":"19 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"6","Issue":"35461","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). Nature Publishing Group: London.  ISSN 2045-2322; e-ISSN 2045-2322","StandardTitleSer":"Scientific Reports (Nature Publishing Group)","ISSN":"2045-2322","AbbrevSer":"NPG Scientific Reports","StandardTitleMon":null,"StartPage":null,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Casas","Firstname":"Laura","Initials":"L.","Affiliation":"KAUST, Div Biol & Environm Sci & Engn, Red Sea Res Ctr, Thuwal 239556900, Saudi Arabia.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298689,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Saborido-Rey","Firstname":"Fran","Initials":"F.","Affiliation":"CSIC, IIM, Inst Marine Res, Vigo 36208, Spain.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298690,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ryu","Firstname":"Taewoo","Initials":"T.","Affiliation":"King Abdullah Univ Sci & Technol, Div Appl Math & Comp Sci, Div Biol & Environm Sci & Engn, KAUST Environm Epigenet Program KEEP, Thuwal 239556900, Saudi Arabia.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298691,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Michell","Firstname":"Craig","Initials":"C.","Affiliation":"KAUST, Div Biol & Environm Sci & Engn, Red Sea Res Ctr, Thuwal 239556900, Saudi Arabia.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298692,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ravasi","Firstname":"Timothy","Initials":"T.","Affiliation":"King Abdullah Univ Sci & Technol, Div Appl Math & Comp Sci, Div Biol & Environm Sci & Engn, KAUST Environm Epigenet Program KEEP, Thuwal 239556900, Saudi Arabia.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298693,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Irigoien","Firstname":"Xabier","Initials":"X.","Affiliation":"KAUST, Div Biol & Environm Sci & Engn, Red Sea Res Ctr, Thuwal 239556900, Saudi Arabia.","Discriminator":null,"CorporateFlag":0,"BEntID":273226,"AutID":298694,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":295960,"LibID":36,"BRefID":281207,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"295960","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":273226,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":273226,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"http://dx.doi.org/10.1038/srep35461","externalID":"10.1038/srep35461","URLTypeCode":"DOI","URLID":51516,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2016-10-18 09:31:01.263000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-02-13 19:34:46.407000","timezone_type":3,"timezone":"Europe/Brussels"}}}