{"refrec":{"BRefID":283405,"RR":"<b>Paulus, C.; Rebets, Y.; Tokovenko, B.; Nadmid, S.; Terekhova, L.P.; Myronovskyi, M.; Zotchev, S.B.; Rückert, C.; Braig, S.; Zahler, S.; Kalinowski, J.; Luzhetskyy, A.</b> (2017). New natural products identified by combined genomics-metabolomics profiling of marine <i>Streptomyces</i> sp. MP131-18. <i>NPG Scientific Reports 7(42382)</i>: 11 pp. <a href=\"http://dx.doi.org/10.1038/srep42382\" target=\"_blank\">http://dx.doi.org/10.1038/srep42382</a>","BEntID":275423,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 7(42382)</i>: 11 pp. <a href=\"http://dx.doi.org/10.1038/srep42382\" target=\"_blank\">http://dx.doi.org/10.1038/srep42382</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Paulus, C.; Rebets, Y.; Tokovenko, B.; Nadmid, S.; Terekhova, L.P.; Myronovskyi, M.; Zotchev, S.B.; Rückert, C.; Braig, S.; Zahler, S.; Kalinowski, J.; Luzhetskyy, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Paulus, C. <i>et al.</i>","Englishabstract":"Marine actinobacteria are drawing more and more attention as a promising source of new natural products. Here we report isolation, genome sequencing and metabolic profiling of new strain Streptomyces sp. MP131-18 isolated from marine sediment sample collected in the Trondheim Fjord, Norway. The 16S rRNA and multilocus phylogenetic analysis showed that MP131-18 belongs to the genus Streptomyces. The genome of MP131-18 isolate was sequenced, and 36 gene clusters involved in the biosynthesis of 18 different types of secondary metabolites were predicted using antiSMASH analysis. The combined genomics-metabolics profiling of the strain led to the identification of several new biologically active compounds. As a result, the family of bisindole pyrroles spiroindimicins was extended with two new members, spiroindimicins E and F. Furthermore, prediction of the biosynthetic pathway for unusual alpha-pyrone lagunapyrone isolated from MP131-18 resulted in foresight and identification of two new compounds of this family - lagunapyrones D and E. The diversity of identified and predicted compounds from Streptomyces sp. MP131-18 demonstrates that marine-derived actinomycetes are not only a promising source of new natural products, but also represent a valuable pool of genes for combinatorial biosynthesis of secondary metabolites.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"New natural products identified by combined genomics-metabolomics profiling of marine <i>Streptomyces</i> sp. 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