{"refrec":{"BRefID":284969,"RR":"<b>Wang, G.; Zhen, Y.; Yu, Z.; Shi, Y.; Zhao, Q.; Wang, J.</b> (2017). The physiological and molecular response of <i>Aurelia</i> sp.1 under hypoxia. <i>NPG Scientific Reports 7(1)</i>: 12 pp. <a href=\"https://dx.doi.org/10.1038/s41598-017-01318-x\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-017-01318-x</a>","BEntID":276993,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 7(1)</i>: 12 pp. <a href=\"https://dx.doi.org/10.1038/s41598-017-01318-x\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-017-01318-x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Wang, G.; Zhen, Y.; Yu, Z.; Shi, Y.; Zhao, Q.; Wang, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Wang, G. <i>et al.</i>","Englishabstract":"Few studies have been published on the mechanisms of hypoxia response and tolerance in jellyfish, especially with respect to the regulatory mechanism at the molecular level. In this study, <i>Aurelia</i> sp.1, which is frequently found in Chinese coastal waters, was cultivated in a hypoxic system to determine the molecular mechanisms underlying its hypoxic response by studying the physiological activity, gene expression and metabolite contents in the prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) oxygen-sensing system. Physiological activity; the expression of PHD, HIF, ALDO (fructose-bisphosphate aldolase), PDK (pyruvate dehydrogenase kinase), and LDH (lactate dehydrogenase) genes; and the lactic acid content in medusae were significantly affected by hypoxia. The up-regulation of ALDO, PDK and LDH, which was directly or indirectly induced by HIF, mediated the transition from aerobic respiration to anaerobic glycolysis in the medusae. In polyps, there was a slight increase in the expression of HIF, PHD and ALDO, no obvious change in that of PDK and a slight decrease in that of LDH throughout the experiment; however, these changes were insufficient to induce the shift. This study provides a scientific basis for elucidating the regulatory mechanism underlying the PHD-HIF oxygen-sensing system in <i>Aurelia</i> sp.1.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The physiological and molecular response of <i>Aurelia</i> sp.1 under hypoxia","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-30 01:31:36.387022","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-05-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000400874400006","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-017-01318-x"},"refs":null,"anarec":{"AnaID":284969,"PubliDate":2017,"Pagination":"12 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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