{"refrec":{"BRefID":285610,"RR":"<b>Gomes, N.G.M.; Dasari, R.; Chandra, S.; Kiss, R.; Kornienko, A.</b> (2016). Marine invertebrate metabolites with anticancer activities: solutions to the \"supply problem\". <i>Mar. Drugs 14(5)</i>: 98. <a href=\"https://dx.doi.org/10.3390/md14050098\" target=\"_blank\">https://dx.doi.org/10.3390/md14050098</a>","BEntID":277635,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 14(5)</i>: 98. <a href=\"https://dx.doi.org/10.3390/md14050098\" target=\"_blank\">https://dx.doi.org/10.3390/md14050098</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Gomes, N.G.M.; Dasari, R.; Chandra, S.; Kiss, R.; Kornienko, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Gomes, N.G.M. <i>et al.</i>","Englishabstract":"Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. 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