{"refrec":{"BRefID":287844,"RR":"<b>Cheng, Z.-B.; Xiao, H.; Fan, C.-Q.; Lu, Y.-N.; Zhang, G.; Yin, S.</b> (2013). Bioactive polyhydroxylated sterols from the marine sponge <i>Haliclona crassiloba</i>. <i>Steroids 78(14)</i>: 1353-1358. <a href=\"https://dx.doi.org/10.1016/j.steroids.2013.10.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.steroids.2013.10.004</a>","BEntID":279869,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Steroids 78(14)</i>: 1353-1358. <a href=\"https://dx.doi.org/10.1016/j.steroids.2013.10.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.steroids.2013.10.004</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Cheng, Z.-B.; Xiao, H.; Fan, C.-Q.; Lu, Y.-N.; Zhang, G.; Yin, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Cheng, Z.-B. <i>et al.</i>","Englishabstract":"Four new polyhydroxylated sterols, named halicrasterols A–D (1–4), together with six known analogs (5–10) were isolated from the marine sponge <i>Haliclona crassiloba</i>. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)<i>E</i>-double bonds. The structures of 1–10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1–10 were evaluated against a panel of bacterial and fungal strains <i>in vitro</i>, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 μg/mL.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Bioactive polyhydroxylated sterols from the marine sponge <i>Haliclona crassiloba</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Polyhydroxylated sterols, Structure elucidation, Antibacterial activity, Haliclona crassiloba","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-08-10","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000328303300007","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.steroids.2013.10.004"},"refs":null,"anarec":{"AnaID":287844,"PubliDate":2013,"Pagination":"1353-1358","XtraPublOfAnaID":null,"ISBN":null,"Volume":"78","Issue":"14","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":278859,"SerRR":"Steroids. 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