Document of bibliographic reference 287844
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba
- Abstract
- Four new polyhydroxylated sterols, named halicrasterols A–D (1–4), together with six known analogs (5–10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1–10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1–10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 μg/mL.
- WebOfScience code
- https://www.webofscience.com/wos/woscc/full-record/WOS:000328303300007
- Bibliographic citation
- Cheng, Z.-B.; Xiao, H.; Fan, C.-Q.; Lu, Y.-N.; Zhang, G.; Yin, S. (2013). Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba. Steroids 78(14): 1353-1358. https://dx.doi.org/10.1016/j.steroids.2013.10.004
- Topic
- Marine
- Is peer reviewed
- true
Authors
- author
-
- Name
- Zhong-Bin Cheng
- author
-
- Name
- Han Xiao
- author
-
- Name
- Cheng-Qi Fan
- author
-
- Name
- Ya-Nan Lu
- author
-
- Name
- Ge Zhang
- author
-
- Name
- Sheng Yin