{"refrec":{"BRefID":288559,"RR":"<b>Sharma, V.; Sarkar, I.N.</b> (2013). Leveraging biodiversity knowledge for potential phyto-therapeutic applications. <i>Journal of the American Medical Informatics Association 20(4)</i>: 668-679. <a href=\"https://dx.doi.org/10.1136/amiajnl-2012-001445\" target=\"_blank\">https://dx.doi.org/10.1136/amiajnl-2012-001445</a>","BEntID":280592,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Journal of the American Medical Informatics Association 20(4)</i>: 668-679. <a href=\"https://dx.doi.org/10.1136/amiajnl-2012-001445\" target=\"_blank\">https://dx.doi.org/10.1136/amiajnl-2012-001445</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sharma, V.; Sarkar, I.N.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sharma, V.; Sarkar, I.N.","Englishabstract":"Objective: To identify and highlight the feasibility, challenges, and advantages of providing a cross-domain pipeline that can link relevant biodiversity information for phyto-therapeutic assessment. Materials and methods: A public repository of clinical trials information (ClinicalTrials.gov) was explored to determine the state of plant-based interventions under investigation. Results: The results showed that ∼15% of drug interventions in ClinicalTrials.gov were potentially plant related, with about 60% of them clustered within 10 taxonomic families. Further analysis of these plant-based interventions identified ∼3.7% of associated plant species as endangered as determined from the International Union for the Conservation of Nature Red List.Discussion: The diversity of the plant kingdom has provided human civilization with life-sustaining food and medicine for centuries. There has been renewed interest in the investigation of botanicals as sources of new drugs, building on traditional knowledge about plant-based medicines. However, data about the plant-based biodiversity potential for therapeutics (eg, based on genetic or chemical information) are generally scattered across a range of sources and isolated from contemporary pharmacological resources. This study explored the potential to bridge biodiversity and biomedical knowledge sources. Conclusions: The findings from this feasibility study suggest that there is an opportunity for developing plant-based drugs and further highlight taxonomic relationships between plants that may be rich sources for bioprospecting.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Leveraging biodiversity knowledge for potential phyto-therapeutic applications","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"biodiversity informatics, bioprospecting, medicinal plants, clinical trials","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-08-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000320168600011","VABBcode":null,"OpenAcc":1,"DOI":"10.1136/amiajnl-2012-001445"},"refs":null,"anarec":{"AnaID":288559,"PubliDate":2013,"Pagination":"668-679","XtraPublOfAnaID":null,"ISBN":null,"Volume":"20","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":273384,"SerRR":"Journal of the American Medical Informatics Association. 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ISSN 1067-5027; e-ISSN 1527-974X","StandardTitleSer":"Journal of the American Medical Informatics Association","ISSN":"1067-5027","AbbrevSer":null,"StandardTitleMon":null,"StartPage":668,"Pages":12,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Sharma","Firstname":"Vivekanand","Initials":"V.","Affiliation":"Univ Vermont, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA.","Discriminator":null,"CorporateFlag":0,"BEntID":280592,"AutID":294706,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sarkar","Firstname":"Indra Neil","Initials":"I.N.","Affiliation":"Univ Vermont, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA.","Discriminator":null,"CorporateFlag":0,"BEntID":280592,"AutID":294707,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":308636,"LibID":36,"BRefID":288559,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"308636","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"OXFORD UNIV PRESS","City":"Oxford"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"955":{"SpName":"Catalogue of Life acknowledged","SpColID":955,"ParSpColID":null,"TopParID":null,"ShortName":"Catalogue of Life ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"Catalogue of Life ackn"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":280592,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":280592,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1136/amiajnl-2012-001445","externalID":"10.1136/amiajnl-2012-001445","URLTypeCode":"DOI","URLID":57463,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"VLIZ2000\\sielc","newSesDate":{"date":"2017-08-22 12:34:58.687000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-02-13 19:34:46.407000","timezone_type":3,"timezone":"Europe/Brussels"}}}