{"refrec":{"BRefID":288791,"RR":"<b>Chen, Y.-S.; Yu, H.-M.; Shie, J.-J.; Cheng, T.-J.R.; Wu, C.-Y.; Fang, J.-M.; Wong, C.-H.</b> (2014). Chemical constituents of <i>Plectranthus amboinicus</i> and the synthetic analogs possessing anti-inflammatory activity. <i>Bioorg. Med. Chem. 22(5)</i>: 1766-1772. <a href=\"https://dx.doi.org/10.1016/j.bmc.2014.01.009\" target=\"_blank\">https://dx.doi.org/10.1016/j.bmc.2014.01.009</a>","BEntID":280827,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Bioorg. Med. Chem. 22(5)</i>: 1766-1772. <a href=\"https://dx.doi.org/10.1016/j.bmc.2014.01.009\" target=\"_blank\">https://dx.doi.org/10.1016/j.bmc.2014.01.009</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Chen, Y.-S.; Yu, H.-M.; Shie, J.-J.; Cheng, T.-J.R.; Wu, C.-Y.; Fang, J.-M.; Wong, C.-H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Chen, Y.-S. <i>et al.</i>","Englishabstract":"This study demonstrates that compounds 1–4 from an extract of <i>Plectranthus amboinicus</i> inhibit the binding of AP-1 to its consensus DNA sequence. Thymoquinone (5) was further identified as a nonpolar ingredient from the hexane extract of <i>P. amboinicus</i> to suppress the expression of lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-α). We then synthesized 2-alkylidenyl-4-cyclopentene-1,3-diones as the designed biomimetics of thymoquinone, and found that compounds 8a, 8b and 8dwere more potent TNF-α inhibitors.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Chemical constituents of <i>Plectranthus amboinicus</i> and the synthetic analogs possessing anti-inflammatory activity","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-15 01:33:00.598078","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Plectranthus amboinicus; Anti-inflammation; Rosmarinic acid; Thymoquinone; 2-Alkylidenyl-4-cyclopentene-1,3-diones","OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-08-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000331729500025","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.bmc.2014.01.009"},"refs":null,"anarec":{"AnaID":288791,"PubliDate":2014,"Pagination":"1766-1772","XtraPublOfAnaID":null,"ISBN":null,"Volume":"22","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":258824,"SerRR":"Bioorganic & Medicinal Chemistry. 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