{"refrec":{"BRefID":289025,"RR":"<b>Inserra, M.C.; Israel, M.R.; Caldwell, A.; Castro, J.; Deuis, J.R.; Harrington, A.M.; Keramidas, A.; Garcia-Caraballo, S.; Maddern, J.; Erickson, A.; Grundy, L.; Rychkov, G.Y.; Zimmermann, K.; Lewis, R.J.; Brierley, S.M.; Vetter, I.</b> (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. <i>NPG Scientific Reports 7</i>: 42810. <a href=\"https://dx.doi.org/10.1038/srep42810\" target=\"_blank\">https://dx.doi.org/10.1038/srep42810</a>","BEntID":281061,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 7</i>: 42810. <a href=\"https://dx.doi.org/10.1038/srep42810\" target=\"_blank\">https://dx.doi.org/10.1038/srep42810</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Inserra, M.C.; Israel, M.R.; Caldwell, A.; Castro, J.; Deuis, J.R.; Harrington, A.M.; Keramidas, A.; Garcia-Caraballo, S.; Maddern, J.; Erickson, A.; Grundy, L.; Rychkov, G.Y.; Zimmermann, K.; Lewis, R.J.; Brierley, S.M.; Vetter, I.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Inserra, M.C. <i>et al.</i>","Englishabstract":"Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (Na<sub>V</sub>), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of the most potent congener, Pacific ciguatoxin-1 (P-CTX-1), on Na<sub>V</sub>1.1–1.9 using imaging and electrophysiological approaches. Although P-CTX-1 is essentially a non-selective Na<sub>V</sub> toxin and shifted the voltage-dependence of activation to more hyperpolarising potentials at all Na<sub>V</sub> subtypes, an increase in the inactivation time constant was observed only at Na<sub>V</sub>1.8, while the slope factor of the conductance-voltage curves was significantly increased for Na<sub>V</sub>1.7 and peak current was significantly increased for Na<sub>V</sub>1.6. Accordingly, P-CTX-1-induced visceral and cutaneous pain behaviours were significantly decreased after pharmacological inhibition of Na<sub>V</sub>1.8 and the tetrodotoxin-sensitive isoforms Na<sub>V</sub>1.7 and Na<sub>V</sub>1.6, respectively. The contribution of these isoforms to excitability of peripheral C- and A-fibre sensory neurons, confirmed using murine skin and visceral single-fibre recordings, reflects the expression pattern of Na<sub>V</sub> isoforms in peripheral sensory neurons and their contribution to membrane depolarisation, action potential initiation and propagation.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-29 01:31:19.749549","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-09-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000394760100001","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/srep42810"},"refs":null,"anarec":{"AnaID":289025,"PubliDate":2017,"Pagination":"42810","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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