{"refrec":{"BRefID":289036,"RR":"<b>Jin, A.-H.; Vetter, I.; Himaya, S.W.A.; Alewood, P.F.; Lewis, R.J.; Dutertre, S.</b> (2015). Transcriptome and proteome of <i>Conus planorbis</i> identify the nicotinic receptors as primary target for the defensive venom. <i>Proteomics (Weinh., Print) 15(23-24)</i>: 4030-4040. <a href=\"https://dx.doi.org/10.1002/pmic.201500220\" target=\"_blank\">https://dx.doi.org/10.1002/pmic.201500220</a>","BEntID":281073,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Proteomics 15(23-24)</i>: 4030-4040. <a href=\"https://dx.doi.org/10.1002/pmic.201500220\" target=\"_blank\">https://dx.doi.org/10.1002/pmic.201500220</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Jin, A.-H.; Vetter, I.; Himaya, S.W.A.; Alewood, P.F.; Lewis, R.J.; Dutertre, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Jin, A.-H. <i>et al.</i>","Englishabstract":"Most venomous predators have evolved complex venom primarily to immobilize their prey and secondarily to defend against predators. In a new paradigm, carnivorous marine gastropods of the genus <i>Conus</i> were shown to rapidly and reversibly switch between two types of venoms in response to predatory or defensive stimulus, suggesting that the defensive use of venom may have a more important role in venom evolution and specialization than previously thought. To further investigate this phenomenon, the defensive repertoire of a vermivorous species, <i>Conus planorbis</i>, was deciphered using second-generation sequencing coupled to high-throughput proteomics. The venom gland transcriptome of <i>C. planorbis</i> revealed 182 unique conotoxin precursors from 25 gene superfamilies, with superfamily T dominating in terms of read and paralog numbers. Analysis of the defense-evoked venom revealed that this vermivorous species uses a similarly complex arsenal to deter aggressors as more recently evolved fish- and mollusk-hunting species, with MS/MS validating 23 conotoxin sequences from six superfamilies. Pharmacological characterization of the defensive venom on human receptors identified the nicotinic acetylcholine receptors as a primary target. This work provides the first insights into the composition and biological activity of specifically evolved defensive venoms in vermivorous cone snails.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Transcriptome and proteome of <i>Conus planorbis</i> identify the nicotinic receptors as primary target for the defensive venom","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-06-21 01:32:25.856657","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"    Animal proteomics;Conotoxin;Conus planorbis;Mass spectrometry;Nicotinic receptors;Venomics","OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-09-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000367728000011","VABBcode":null,"OpenAcc":0,"DOI":"10.1002/pmic.201500220"},"refs":null,"anarec":{"AnaID":289036,"PubliDate":2015,"Pagination":"4030-4040","XtraPublOfAnaID":null,"ISBN":null,"Volume":"15","Issue":"23-24","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":220678,"SerRR":"Proteomics. 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ISSN 1615-9853; e-ISSN 1615-9861","StandardTitleSer":"Proteomics","ISSN":"1615-9853","AbbrevSer":"Proteomics","StandardTitleMon":null,"StartPage":4030,"Pages":11,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Jin","Firstname":"Ai-Hua","Initials":"A.-H.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":269693,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vetter","Firstname":"Irina","Initials":"I.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":269058,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-3594-9588","PersID":35152,"InsID":null},{"AutName":"Himaya","Firstname":"Siddhihalu","Initials":"S.W.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":269729,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Alewood","Firstname":"Paul","Initials":"P.F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":269698,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Lewis","Firstname":"Richard","Initials":"R.J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":27572,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Dutertre","Firstname":"Sébastien","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":281073,"AutID":269694,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":306139,"LibID":36,"BRefID":289036,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"306139","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Wiley-VCH","City":"Weinheim"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":281073,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":281073,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1002/pmic.201500220","externalID":"10.1002/pmic.201500220","URLTypeCode":"DOI","URLID":57921,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2017-09-07 08:21:56.400000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-02-13 19:34:46.407000","timezone_type":3,"timezone":"Europe/Brussels"}}}