{"refrec":{"BRefID":289043,"RR":"<b>Zimmermann, K.; Deuis, J.R.; Inserra, M.C.; Collins, L.S.; Namer, B.; Cabot, P.J.; Reeh, P.W.; Lewis, R.J.; Vetter, I.</b> (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. <i>Pain 154(10)</i>: 1999-2006. <a href=\"https://dx.doi.org/10.1016/j.pain.2013.06.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.pain.2013.06.015</a>","BEntID":281080,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Pain 154(10)</i>: 1999-2006. <a href=\"https://dx.doi.org/10.1016/j.pain.2013.06.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.pain.2013.06.015</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zimmermann, K.; Deuis, J.R.; Inserra, M.C.; Collins, L.S.; Namer, B.; Cabot, P.J.; Reeh, P.W.; Lewis, R.J.; Vetter, I.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zimmermann, K. <i>et al.</i>","Englishabstract":"Ciguatera, the most common form of nonbacterial ichthyosarcotoxism, is caused by consumption of fish that have bioaccumulated the polyether sodium channel activator ciguatoxin. The neurological symptoms of ciguatera include distressing, often persistent sensory disturbances such as paraesthesias and the pathognomonic symptom of cold allodynia. We show that intracutaneous administration of ciguatoxin in humans elicits a pronounced axon‐reflex flare and replicates cold allodynia. To identify compounds able to inhibit ciguatoxin‐induced Na<sub>v</sub> responses, we developed a novel in vitro ciguatoxin assay using the human neuroblastoma cell line SH‐SY5Y. Pharmacological characterisation of this assay demonstrated a major contribution of Na<sub>v</sub>1.2 and Na<sub>v</sub>1.3, but not Na<sub>v</sub>1.7, to ciguatoxin‐induced Ca<sup>2+</sup> responses. Clinically available Na<sub>v</sub> inhibitors, as well as the K<sub>v</sub>7 agonist flupirtine, inhibited tetrodotoxin‐sensitive ciguatoxin‐evoked responses. To establish their in vivo efficacy, we used a novel animal model of ciguatoxin‐induced cold allodynia. However, differences in the efficacy of these compounds to reverse ciguatoxin‐induced cold allodynia did not correlate with their potency to inhibit ciguatoxin‐induced responses in SH‐SY5Y cells or at heterologously expressed Na<sub>v</sub>1.3, Na<sub>v</sub>1.6, Na<sub>v</sub>1.7, or Na<sub>v</sub>1.8, indicating cold allodynia might be more complex than simple activation of Na<sub>v</sub> channels. These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Analgesic treatment of ciguatoxin-induced cold allodynia","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:32:52.928458","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Allodynia; Ciguatoxin; Cold pain; Nociceptor; Peripheral; Sensoryneuropathy","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-09-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000324475500017","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.pain.2013.06.015"},"refs":null,"anarec":{"AnaID":289043,"PubliDate":2013,"Pagination":"1999-2006","XtraPublOfAnaID":null,"ISBN":null,"Volume":"154","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":275966,"SerRR":"Pain. 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