{"refrec":{"BRefID":289047,"RR":"<b>Sousa, S.; Vetter, I.; Lewis, R.</b> (2013). Venom peptides as a rich source of Ca<sub>v</sub>2.2 channel blockers. <i>Toxins 5(2)</i>: 286-314. <a href=\"https://dx.doi.org/10.3390/toxins5020286\" target=\"_blank\">https://dx.doi.org/10.3390/toxins5020286</a>","BEntID":281084,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Toxins 5(2)</i>: 286-314. <a href=\"https://dx.doi.org/10.3390/toxins5020286\" target=\"_blank\">https://dx.doi.org/10.3390/toxins5020286</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sousa, S.; Vetter, I.; Lewis, R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sousa, S. <i>et al.</i>","Englishabstract":"Ca<sub>v</sub>2.2 is a calcium channel subtype localized at nerve terminals, including nociceptive fibers, where it initiates neurotransmitter release. Ca<sub>v</sub>2.2 is an important contributor to synaptic transmission in ascending pain pathways, and is up-regulated in the spinal cord in chronic pain states along with the auxiliary <i>α2δ</i>1 subunit. It is therefore not surprising that toxins that inhibit Ca<sub>v</sub>2.2 are analgesic. Venomous animals, such as cone snails, spiders, snakes, assassin bugs, centipedes and scorpions are rich sources of remarkably potent and selective Ca<sub>v</sub>2.2 inhibitors. However, side effects in humans currently limit their clinical use. Here we review Ca<sub>v</sub>2.2 inhibitors from venoms and their potential as drug leads.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Venom peptides as a rich source of Ca<sub>v</sub>2.2 channel blockers","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":" Cav2.2; voltage-gated calcium channels; nociception; neurotransmitter; ?-conotoxins; venom peptides","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-09-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000315408000005","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/toxins5020286"},"refs":null,"anarec":{"AnaID":289047,"PubliDate":2013,"Pagination":"286-314","XtraPublOfAnaID":null,"ISBN":null,"Volume":"5","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":197331,"SerRR":"Toxins. 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