{"refrec":{"BRefID":289347,"RR":"<b>Saxena, S.; Dupont, S.; Meghah, V.; Lakshmi, M.G.M.; Singh, S.K.; Swamy, C.V.B.; Idris, M.M.</b> (2013). Proteome map of the neural complex of the tunicate <i>Ciona intestinalis</i>, the closest living relative to vertebrates. <i>Proteomics (Weinh., Print) 13(5)</i>: 860-865. <a href=\"https://dx.doi.org/10.1002/pmic.201200148\" target=\"_blank\">https://dx.doi.org/10.1002/pmic.201200148</a>","BEntID":281384,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Proteomics 13(5)</i>: 860-865. <a href=\"https://dx.doi.org/10.1002/pmic.201200148\" target=\"_blank\">https://dx.doi.org/10.1002/pmic.201200148</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Saxena, S.; Dupont, S.; Meghah, V.; Lakshmi, M.G.M.; Singh, S.K.; Swamy, C.V.B.; Idris, M.M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Saxena, S. <i>et al.</i>","Englishabstract":"<i>Ciona intestinalis</i> (the common sea squirt) is the closest living chordate relative to vertebrates with cosmopolitan presence worldwide. It has a relatively simple nervous system and development, making it a widely studied alternative model system in neuroscience and developmental biology. The use of <i>Ciona</i> as a model organism has increased significantly after the draft genome was published. In this study, we describe the first proteome map of the neural complex of <i>C. intestinalis</i>. A total of 544 proteins were identified based on 1DE and 2DE FTMS/ITMSMS analyses. Proteins were annotated against the <i>Ciona</i> database and analyzed to predict their molecular functions, roles in biological processes, and position in constructed network pathways. The identified <i>Ciona</i> neural complex proteome was found to map onto vertebrate nervous system pathways, including cytoskeleton remodeling neurofilaments, cell adhesion through the histamine receptor signaling pathway, γ-aminobutyric acid-A receptor life cycle neurophysiological process, glycolysis, and amino acid metabolism. 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