{"refrec":{"BRefID":289745,"RR":"<b>Cao, C.; Shao, C.-L.; Liu, Y.-F.; Zhu, H.-J.; Wang, C.-Y.</b> (2017). Cytotoxic serrulatane-type diterpenoids from the Gorgonian <i>Euplexaura</i> sp. and their absolute configurations by vibrational circular dichroism. <i>NPG Scientific Reports 7(1)</i>: 8 pp. <a href=\"https://dx.doi.org/10.1038/s41598-017-12841-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-017-12841-2</a>","BEntID":281784,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 7(1)</i>: 8 pp. <a href=\"https://dx.doi.org/10.1038/s41598-017-12841-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-017-12841-2</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Cao, C.; Shao, C.-L.; Liu, Y.-F.; Zhu, H.-J.; Wang, C.-Y.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Cao, C. <i>et al.</i>","Englishabstract":"Vibrational circular dichroism (VCD) method has become robust and reliable alternative for the stereochemical characterization of natural products. In this paper, three new serrulatane-type diterpenoids, euplexaurenes A–C (1–3), and a known metabolite, anthogorgiene P (4), were obtained from the South China Sea gorgonian Euplexaura sp. GXWZ-05. The absolute configuration of C-11 in 1–4, which was difficult to be determined by common means due to the high conformational flexibility of the eight-carbon aliphatic chain attached at C-4, was determined by VCD method, suggesting a new horizon to define the absolute configurations of natural products possessing chains. Compounds 1–4 were found to show selective cytotoxic activities against human laryngeal carcinoma (Hep-2) cell line with the IC50 values of 1.95, 7.80, 13.6 and 5.85 μM, respectively.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Cytotoxic serrulatane-type diterpenoids from the Gorgonian <i>Euplexaura</i> sp. and their absolute configurations by vibrational circular dichroism","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-13 01:31:33.823525","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2017-10-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000412050100069","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-017-12841-2"},"refs":null,"anarec":{"AnaID":289745,"PubliDate":2017,"Pagination":"8 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"7","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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