{"refrec":{"BRefID":292166,"RR":"<b>Alzoubi, K.H.; Rawashdeh, N.Q.; Khabour, O.F.; El-Elimat, T.; Albataineh, H.; Al-Zghool, H.M.; Alali, F.Q.</b> (2017). Evaluation of the effect of <i>Moringa peregrina</i> extract on learning and memory: role of oxidative stress. <i>Journal of Molecular Neuroscience 63(3-4)</i>: 355-363. <a href=\"https://dx.doi.org/10.1007/s12031-017-0986-x\" target=\"_blank\">https://dx.doi.org/10.1007/s12031-017-0986-x</a>","BEntID":284217,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Journal of Molecular Neuroscience 63(3-4)</i>: 355-363. <a href=\"https://dx.doi.org/10.1007/s12031-017-0986-x\" target=\"_blank\">https://dx.doi.org/10.1007/s12031-017-0986-x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Alzoubi, K.H.; Rawashdeh, N.Q.; Khabour, O.F.; El-Elimat, T.; Albataineh, H.; Al-Zghool, H.M.; Alali, F.Q.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Alzoubi, K.H. <i>et al.</i>","Englishabstract":"Oxidative stress interferes with the functional roles of the hippocampus and results in cognitive decline. Antioxidant supplementation has a cognitive enhancing activity through protecting hippocampus brain cells from the damaging effects of the reactive oxygen species. The dried methanolic extract of the aboveground parts of <i>Moringa peregrina</i> (Forssk.) Fiori (Moringaceae) was hypothesized to have memory-enhancing activity via its antioxidative properties. HPLC and LC-MS methods were used for qualitative analysis of the marker compounds. Six major compounds of the methanolic extract of <i>M. peregrina</i> were identified, namely, rutin, myricetin, <i>α</i>-amyrin, <i>β</i>-amyrin, lupeol acetate, and <i>β</i>-sitosterol. Male Wistar rats were administered via oral gavage three dose levels (50, 100, and 500 mg/kg) of <i>M. peregrina</i> methanolic extract for 2 months. The radial arm water maze (RAWM) was used to test spatial learning and memory. In addition, ELISA was used to analyze the levels of brain-derived neurotrophic factor (BDNF) and to assess the level of some oxidative stress markers. <i>M. peregrina</i> (150 mg/kg) resulted in short- and long-term memory enhancement (<i>P <</i> 0.05). Moreover, <i>M. peregrina</i> administration elevated BDNF levels in the hippocampus (<i>P <</i> 0.05) and caused favorable changes in oxidative stress biomarkers. In particular, an increase in glutathione (GSH), a decrease in oxidized glutathione (GSSG), and an increase in the antioxidant enzyme glutathione peroxidase (GPx) levels in the hippocampus were elicited after treatment with <i>M. peregrina</i>. Taken together, our data show that oral administration of <i>M. peregrina</i> enhances both short- and long-term memory functions via combating oxidative stress and increasing BDNF levels in the hippocampus. Consuming this safe plant may thus help promote spatial learning and improve memory.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Evaluation of the effect of <i>Moringa peregrina</i> extract on learning and memory: role of oxidative stress","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Moringa peregrina; Cognition; Learning; Memory; Hippocampus; Antioxidant","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2018-01-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000415983800010","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s12031-017-0986-x"},"refs":null,"anarec":{"AnaID":292166,"PubliDate":2017,"Pagination":"355-363","XtraPublOfAnaID":null,"ISBN":null,"Volume":"63","Issue":"3-4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":272633,"SerRR":"Journal of Molecular Neuroscience. 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ISSN 0895-8696; e-ISSN 1559-1166","StandardTitleSer":"Journal of Molecular Neuroscience","ISSN":"0895-8696","AbbrevSer":null,"StandardTitleMon":null,"StartPage":355,"Pages":9,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Alzoubi","Firstname":"Karem","Initials":"K.H.","Affiliation":"Jordan Univ Sci & Technol, Dept Clin Pharm, Fac Pharm, Irbid 22110, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306404,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Rawashdeh","Firstname":"Nasab","Initials":"N.Q.","Affiliation":"Natl Ctr Agr Res & Extens, Amman, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306405,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Khabour","Firstname":"Omar","Initials":"O.F.","Affiliation":"Jordan Univ Sci & Technol, Dept Med Lab Sci, Irbid 22110, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306406,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"El-Elimat","Firstname":"Tamam","Initials":"T.","Affiliation":"Jordan Univ Sci & Technol, Dept Med Chem & Pharmacognosy, Fac Pharm, Irbid 22110, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306407,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Albataineh","Firstname":"Hanan","Initials":"H.","Affiliation":"Jordan Univ Sci & Technol, Dept Med Chem & Pharmacognosy, Fac Pharm, Irbid 22110, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306408,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Al-Zghool","Firstname":"Hamzeh","Initials":"H.M.","Affiliation":"Hashemite Univ, Fac Med, Zarqa, Jordan.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306409,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Alali","Firstname":"Feras","Initials":"F.Q.","Affiliation":"Qatar Univ, Coll Pharm, Doha 2713, Qatar.","Discriminator":null,"CorporateFlag":0,"BEntID":284217,"AutID":306410,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":null,"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Humana Press Inc","City":"Totowa"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"955":{"SpName":"Catalogue of Life acknowledged","SpColID":955,"ParSpColID":null,"TopParID":null,"ShortName":"Catalogue of Life ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"Catalogue of Life ackn"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":284217,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":284217,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1007/s12031-017-0986-x","externalID":"10.1007/s12031-017-0986-x","URLTypeCode":"DOI","URLID":60329,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2018-01-24 08:30:33.010000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-02-13 19:34:46.407000","timezone_type":3,"timezone":"Europe/Brussels"}}}