{"refrec":{"BRefID":2923,"RR":"<b>Chair, M.; Nelis, H.J.; Leger, P.; Sorgeloos, P.; De Leenheer, A.P.</b> (1996). Accumulation of trimethoprim, sulfamethoxazole, and <i>N</i>-acetylsulfamethoxazole in fish and shrimp fed medicated <i>Artemia franciscana</i>. <i>Antimicrob. Agents Chemother. 40(7)</i>: 1649-1652. <a href=\"https://dx.doi.org/10.1128/AAC.40.7.1649\" target=\"_blank\">https://dx.doi.org/10.1128/AAC.40.7.1649</a>","BEntID":2923,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Antimicrob. Agents Chemother. 40(7)</i>: 1649-1652. <a href=\"https://dx.doi.org/10.1128/AAC.40.7.1649\" target=\"_blank\">https://dx.doi.org/10.1128/AAC.40.7.1649</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Chair, M.; Nelis, H.J.; Leger, P.; Sorgeloos, P.; De Leenheer, A.P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Chair, M. <i>et al.</i>","Englishabstract":"In a previous paper (H.J. Nelis, P. Léger, P. Sorgeloos, and A.P. De Leenheer, Antimicrob. Agents Chemother. 35:2486-2489, 1991) it was reported that two selected antibacterial agents, i.e. trimethoprim and sulfamethoxazole, can be efficiently bioencapsulated in nauplii of the brine shrimp <i><i>Artemia</i> franciscana</i> for administration to fish. This follow-up study showed that larvae of the sea bass and the turbot as well as postlarvae of the white shrimp accumulate the therapeutic agents in high quantities when fed medicated <i>A. franciscana</i>. To monitor their levels as a function of time, the liquid chromatographic method originally developed for the analysis of <i>A. franciscana</i> was modified with respect to chromatography, internal standardization, and sample pretreatment. The levels of trimethoprim ranged from 1 to 7 µg/g (sea bass), 1 to 13µg/g (turbot), and 4 to 38 µg/g (white shrimp). The corresponding values for sulfamethoxazole were 0.3 to 4 µg/g (sea bass), 1 to 42 µg/g (turbot), and 4 to 35µg/g (white shrimp). Only the two fish species, unlike the shrimp, metabolized the latter to <i>N</i>-acetylsulfamethoxazole (concentration range, 1 to 10 µg/g). These data suggest the potential of the bioencapsulation of therapeutic agents in live food as a tool to control infectious diseases in aquaculture. A preliminary challenge test also confirmed the in vivo efficacy of this approach.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Accumulation of trimethoprim, sulfamethoxazole, and <i>N</i>-acetylsulfamethoxazole in fish and shrimp fed medicated <i>Artemia franciscana</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-28 01:31:00.800905","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1996,"MonPub":null,"DateUpdate":"2003-04-08","DateCreate":"2000-08-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1996UW37900014","VABBcode":null,"OpenAcc":0,"DOI":"10.1128/AAC.40.7.1649"},"refs":null,"anarec":{"AnaID":2923,"PubliDate":1996,"Pagination":"1649-1652","XtraPublOfAnaID":null,"ISBN":null,"Volume":"40","Issue":"7","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42356,"SerRR":"Antimicrobial agents and chemotherapy. American Society for Microbiology: Washington, D.C..  ISSN 0066-4804; e-ISSN 1098-6596","StandardTitleSer":"Antimicrobial agents and chemotherapy","ISSN":"0066-4804","AbbrevSer":"Antimicrob. 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