{"refrec":{"BRefID":292369,"RR":"<b>Tettweiler, G.; Kowanda, M.; Lasko, P.; Sonenberg, N.; Hernández, G.</b> (2012). The distribution of eIF4E-family members across Insecta. <i>Comp. Funct. Genomics 2012</i>: 1-15. <a href=\"https://dx.doi.org/10.1155/2012/960420\" target=\"_blank\">https://dx.doi.org/10.1155/2012/960420</a>","BEntID":284421,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". <i>Comp. Funct. Genomics 2012</i>: 1-15. <a href=\"https://dx.doi.org/10.1155/2012/960420\" target=\"_blank\">https://dx.doi.org/10.1155/2012/960420</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tettweiler, G.; Kowanda, M.; Lasko, P.; Sonenberg, N.; Hernández, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tettweiler, G. <i>et al.</i>","Englishabstract":"Insects are part of the earliest faunas that invaded terrestrial environments and are the first organisms that evolved controlled flight. Nowadays, insects are the most diverse animal group on the planet and comprise the majority of extant animal species described. Moreover, they have a huge impact in the biosphere as well as in all aspects of human life and economy; therefore understanding all aspects of insect biology is of great importance. In insects, as in all cells, translation is a fundamental process for gene expression. However, translation in insects has been mostly studied only in the model organism <i>Drosophila melanogaster</i>. We used all publicly available genomic sequences to investigate in insects the distribution of the genes encoding the cap-binding protein eIF4E, a protein that plays a crucial role in eukaryotic translation. We found that there is a diversity of multiple ortholog genes encoding eIF4E isoforms within the genus <i>Drosophila</i>. In striking contrast, insects outside this genus contain only a single eIF4E gene, related to D. melanogaster eIF4E-1. We also found that all insect species here analyzed contain only one Class II gene, termed 4E-HP. 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