{"refrec":{"BRefID":293264,"RR":"<b>Asselman, J.; De Coninck, D.I.M.; Vandegehuchte, M.B.; Jansen, M.; Decaestecker, E.; De Meester, L.; Vanden Bussche, J.; Vanhaecke, L.; Janssen, C.R.; De Schamphelaere, K.A.C.</b> (2015). Global cytosine methylation in <i>Daphnia magna</i> depends on genotype, environment, and their interaction. <i>Environ. Toxicol. Chem. 34(5)</i>: 1056-1061. <a href=\"https://dx.doi.org/10.1002/etc.2887\" target=\"_blank\">https://dx.doi.org/10.1002/etc.2887</a>","BEntID":285318,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Environ. Toxicol. Chem. 34(5)</i>: 1056-1061. <a href=\"https://dx.doi.org/10.1002/etc.2887\" target=\"_blank\">https://dx.doi.org/10.1002/etc.2887</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Asselman, J.; De Coninck, D.I.M.; Vandegehuchte, M.B.; Jansen, M.; Decaestecker, E.; De Meester, L.; Vanden Bussche, J.; Vanhaecke, L.; Janssen, C.R.; De Schamphelaere, K.A.C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Asselman, J. <i>et al.</i>","Englishabstract":"The authors characterized global cytosine methylation levels in 2 different genotypes of the ecotoxicological model organism <i>Daphnia magna</i> after exposure to a wide array of biotic and abiotic environmental stressors. The present study aimed to improve the authors' understanding of the role of cytosine methylation in the organism's response to environmental conditions. The authors observed a significant genotype effect, an environment effect, and a genotype × environment effect. In particular, global cytosine methylation levels were significantly altered after exposure to <i>Triops</i> predation cues, <i>Microcystis</i>, and sodium chloride compared with control conditions. Significant differences between the 2 genotypes were observed when animals were exposed to <i>Triops</i> predation cues, <i>Microcystis</i>, <i>Cryptomonas</i>, and sodium chloride. Despite the low global methylation rate under control conditions (0.49–0.52%), global cytosine methylation levels upon exposure to <i>Triops</i> demonstrated a 5-fold difference between the genotypes (0.21% vs 1.02%). No effects were found in response to arsenic, cadmium, fish, lead, pH of 5.5, pH of 8, temperature, hypoxia, and white fat cell disease. The authors' results point to the potential role of epigenetic effects under changing environmental conditions such as predation (i.e., <i>Triops</i>), diet (i.e., <i>Cryptomonas</i> and <i>Microcystis</i>), and salinity. The results of the present study indicate that, despite global cytosine methylation levels being low, epigenetic effects may be important in environmental studies on <i>Daphnia</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Global cytosine methylation in <i>Daphnia magna</i> depends on genotype, environment, and their interaction","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-26 01:31:47.420476","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Cytosine methylation;Aquatic invertebrate;Environmental toxicology;Epigenetics;Ecotoxicology","OtherDescriptors":null,"Notes":null,"AnaPub":2015,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2018-03-08","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000353412800017","VABBcode":null,"OpenAcc":0,"DOI":"10.1002/etc.2887"},"refs":null,"anarec":{"AnaID":293264,"PubliDate":2015,"Pagination":"1056-1061","XtraPublOfAnaID":null,"ISBN":null,"Volume":"34","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42839,"SerRR":"Environmental Toxicology and Chemistry. Setac Press: New York.  ISSN 0730-7268; e-ISSN 1552-8618","StandardTitleSer":"Environmental Toxicology and Chemistry","ISSN":"0730-7268","AbbrevSer":"Environ. Toxicol. 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