{"refrec":{"BRefID":293268,"RR":"<b>Vandegehuchte, M.; Vandenbrouck, T.; De Coninck, D.; De Coen, W.M.; Janssen, C.</b> (2010). Gene transcription and higher-level effects of multigenerational Zn exposure in <i>Daphnia magna</i>. <i>Chemosphere 80(9)</i>: 1014-1020. <a href=\"https://dx.doi.org/10.1016/j.chemosphere.2010.05.032\" target=\"_blank\">https://dx.doi.org/10.1016/j.chemosphere.2010.05.032</a>","BEntID":285322,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Chemosphere 80(9)</i>: 1014-1020. <a href=\"https://dx.doi.org/10.1016/j.chemosphere.2010.05.032\" target=\"_blank\">https://dx.doi.org/10.1016/j.chemosphere.2010.05.032</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vandegehuchte, M.; Vandenbrouck, T.; De Coninck, D.; De Coen, W.M.; Janssen, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vandegehuchte, M. <i>et al.</i>","Englishabstract":"Zn exposure of <i>Daphnia magna</i> during one generation has been shown to modulate gene transcription differently in Zn exposed organisms compared to their non-exposed offspring. Here we studied the transcriptional gene regulation with a cDNA microarray in <i>D.</i> <i>magna</i> exposed to Zn for three generations (F<sub>0</sub>–F<sub>2</sub>). For the first time molecular effects of multigeneration toxicant exposure in <i>D. magna</i> are described. Out of 73 differentially transcribed genes in the F<sub>1</sub>Zn exposed generation (compared to the F<sub>1</sub> control), only seven genes were also differentially transcribed in the same direction in the F<sub>0</sub>Zn exposed daphnids (up or down, compared to the F<sub>0</sub> control). The majority of the differentially transcribed unigenes in F<sub>1</sub>Zn exposed daphnids (78%) were not differentially transcribed in the F<sub>0</sub>Zn exposed organisms. This indicates that Zn exposure affected other molecular pathways in the second exposed generation, although a reduced reproduction and a reduction in juvenile growth were observed in both Zn exposed generations, compared to the respective controls. In the third Zn exposed generation (F<sub>2</sub>), no reduction in growth or reproduction compared to the control was observed. This acclimation was reflected in a significantly lower number of differentially transcribed genes, compared to the Zn exposed F<sub>0</sub> and F<sub>1</sub> generations.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Gene transcription and higher-level effects of multigenerational Zn exposure in <i>Daphnia magna</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Acclimation; Microarray; Ecotoxicology; Stress; Ecotoxicogenomics","OtherDescriptors":null,"Notes":null,"AnaPub":2010,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2018-03-08","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000280981300008","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.chemosphere.2010.05.032"},"refs":null,"anarec":{"AnaID":293268,"PubliDate":2010,"Pagination":"1014-1020","XtraPublOfAnaID":null,"ISBN":null,"Volume":"80","Issue":"9","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42564,"SerRR":"Chemosphere. 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ISSN 0045-6535; e-ISSN 1879-1298","StandardTitleSer":"Chemosphere","ISSN":"0045-6535","AbbrevSer":"Chemosphere","StandardTitleMon":null,"StartPage":1014,"Pages":7,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Vandegehuchte","Firstname":"Michiel","Initials":"M.","Affiliation":"Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":285322,"AutID":229022,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"GhEnToxLab","InsFSN":"Universiteit Gent; Faculteit Bio-ingenieurswetenschappen; Vakgroep Dierwetenschappen en Aquatische Ecologie; Laboratorium voor Milieutoxicologie","ORCID":"0000-0002-3915-4416","PersID":10749,"InsID":6705},{"AutName":"Vandenbrouck","Firstname":"Tine","Initials":"T.","Affiliation":"Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp","Discriminator":null,"CorporateFlag":0,"BEntID":285322,"AutID":74474,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"Universiteit Antwerpen; 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