{"refrec":{"BRefID":293621,"RR":"<b>Tan, P.; Peng, M.; Liu, D.; Guo, H.; Mai, K.; Nian, R.; Macq, B.; Ai, Q.</b> (2017). Suppressor of cytokine signaling 3 (SOCS3) is related to pro-inflammatory cytokine production and triglyceride deposition in turbot (<i>Scophthalmus maximus</i>). <i>Fish Shellfish Immunol. 70</i>: 381-390. <a href=\"https://dx.doi.org/10.1016/j.fsi.2017.09.006\" target=\"_blank\">https://dx.doi.org/10.1016/j.fsi.2017.09.006</a>","BEntID":285685,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Fish Shellfish Immunol. 70</i>: 381-390. <a href=\"https://dx.doi.org/10.1016/j.fsi.2017.09.006\" target=\"_blank\">https://dx.doi.org/10.1016/j.fsi.2017.09.006</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tan, P.; Peng, M.; Liu, D.; Guo, H.; Mai, K.; Nian, R.; Macq, B.; Ai, Q.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tan, P. <i>et al.</i>","Englishabstract":"Turbot (<i>Scophthalmus maximus</i>) is an economically important fish that is farmed by aquaculture for human consumption. Aquacultured turbot are commonly fed a high-lipid diet; however, this diet causes excessive lipid deposition and the overexpression of pro-inflammatory cytokines. Studies in mammals have indicated that a relationship exists between pro-inflammatory cytokine overexpression and altered lipid metabolism through the activation of suppressor of cytokine signaling 3 (SOCS3). In this study, we investigated the relationship between SOCS3 and triglyceride (TG) deposition and mechanism of SOCS3 activation in farmed turbot fed high-lipid diet (HLD). TG content increased with SOCS3 production, mediated by toll-like receptor-nuclear transcription factor kappa-B (TLR-NFκB) signaling in the liver of turbot fed a HLD and in turbot primary liver cells incubated with oleic acid (OA). Overexpression of <i>SOCS3</i> increased TG deposition via the increased production of mature sterol regulatory element binding protein 1 (m-SREBP-1). Knockdown of SOCS3 in turbot primary liver cells resulted in normalized TG deposition and decreased m-SREBP-1 production. These results suggest that the HLD and OA can induce cytokine expression by activating the TLR-NFκB signaling pathways, resulting in increased SOCS3 expression. It is proposed that SOCS3 enhances m-SREBP-1 production, leading to TG deposition. These findings provide important new insights into the relationship between cytokine expression and TG deposition and mechanism of HLD-induced pro-inflammatory response, which could help to improve the health of farmed turbot and a better understanding of fish immunity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Suppressor of cytokine signaling 3 (SOCS3) is related to pro-inflammatory cytokine production and triglyceride deposition in turbot (<i>Scophthalmus maximus</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-28 01:32:15.666965","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"High-lipid diet; Suppressor of cytokine signaling 3; Toll-likereceptor-nuclear transcription factor kappa-B; Triglyceride; Maturesterol regulatory element binding protein 1","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2020-08-31","DateCreate":"2018-03-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000416186800040","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.fsi.2017.09.006"},"refs":null,"anarec":{"AnaID":293621,"PubliDate":2017,"Pagination":"381-390","XtraPublOfAnaID":null,"ISBN":null,"Volume":"70","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45027,"SerRR":"Fish & Shellfish Immunology. 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