{"refrec":{"BRefID":293735,"RR":"<b>Campos, P.-E.; Wolfender, J.-L.; Queiroz, E.F.; Marcourt, L.; Al-Mourabit, A.; Frederich, M.; Bordignon, A.; De Voogd, N.; Illien, B.; Gauvin-Bialecki, A.</b> (2017). Unguiculin A and ptilomycalins E-H, antimalarial guanidine alkaloids from the marine sponge <i>Monanchora unguiculata</i>. <i>J. Nat. Prod. 80(5)</i>: 1404-1410. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.6b01079\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.6b01079</a>","BEntID":285799,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Nat. Prod. 80(5)</i>: 1404-1410. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.6b01079\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.6b01079</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Campos, P.-E.; Wolfender, J.-L.; Queiroz, E.F.; Marcourt, L.; Al-Mourabit, A.; Frederich, M.; Bordignon, A.; De Voogd, N.; Illien, B.; Gauvin-Bialecki, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Campos, P.-E. <i>et al.</i>","Englishabstract":"Chemical study of the CH<sub>2</sub>Cl<sub>2</sub>–MeOH (1:1) extract from the sponge <i>Monanchora unguiculata</i> collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A and four pentacyclic alkaloids, ptilomycalins E–H, along with four known compounds: crambescidin 800 and crambescidin 359, crambescidic acid, and fromiamycalin. Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E and the mixture of the new ptilomycalins G and H showed promising cytotoxicity against KB cells with IC<sub>50</sub> values of 0.85 and 0.92 μM, respectively. 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