{"refrec":{"BRefID":293748,"RR":"<b>Issac, M.; Aknin, M.; Gauvin-Bialecki, A.; De Voogd, N.; Ledoux, A.; Frederich, M.; Kashman, Y.; Carmeli, S.</b> (2017). Cyclotheonellazoles A-C, potent protease inhibitors from the marine sponge <i>Theonella</i> aff. <i>swinhoei</i>. <i>J. Nat. Prod. 80(4)</i>: 1110-1116. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.7b00028\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.7b00028</a>","BEntID":285812,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Nat. Prod. 80(4)</i>: 1110-1116. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.7b00028\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.7b00028</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Issac, M.; Aknin, M.; Gauvin-Bialecki, A.; De Voogd, N.; Ledoux, A.; Frederich, M.; Kashman, Y.; Carmeli, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Issac, M. <i>et al.</i>","Englishabstract":"The extract of a sample of the sponge <i>Theonella</i> aff. <i>swinhoei</i> collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known metabolite swinholide A. Further investigation of the extract afforded three unusual cyclic peptides, cyclotheonellazoles A–C, which contain six nonproteinogenic amino acids out of the eight acid units that compose these natural products. Among these acids the most novel were 4-propenoyl-2-tyrosylthiazole and 3-amino-4-methyl-2-oxohexanoic acid. The structure of the compounds was elucidated by interpretation of the 1D and 2D NMR data, HRESIMS, and advanced Merfay’s techniques. The new compounds were found to be nanomolar inhibitors of chymotrypsin and sub-nanomolar inhibitors of elastase, but did not present antiplasmodial activity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Cyclotheonellazoles A-C, potent protease inhibitors from the marine sponge <i>Theonella</i> aff. <i>swinhoei</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-02 01:31:52.068392","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2019-07-09","DateCreate":"2018-03-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000400538800041","VABBcode":null,"OpenAcc":0,"DOI":"10.1021/acs.jnatprod.7b00028"},"refs":null,"anarec":{"AnaID":293748,"PubliDate":2017,"Pagination":"1110-1116","XtraPublOfAnaID":null,"ISBN":null,"Volume":"80","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43089,"SerRR":"Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC.  ISSN 0163-3864; e-ISSN 1520-6025","StandardTitleSer":"Journal of Natural Products","ISSN":"0163-3864","AbbrevSer":"J. Nat. Prod.","StandardTitleMon":null,"StartPage":1110,"Pages":7,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Issac","Firstname":"Michal","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":318927,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Aknin","Firstname":"Maurice","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":17778,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Gauvin-Bialecki","Firstname":"Anne","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":320593,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"De Voogd","Firstname":"Nicole","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":320592,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-7985-5604","PersID":16327,"InsID":null},{"AutName":"Ledoux","Firstname":"Alisson","Initials":"A.","Affiliation":"Laboratory of Pharmacognosy, Department of Pharmacy, CIRM, University of Liège","Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":318929,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-4052-6336","PersID":45168,"InsID":null},{"AutName":"Frederich","Firstname":"Michel","Initials":"M.","Affiliation":"Laboratory of Pharmacognosy, Department of Pharmacy, CIRM, University of Liége","Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":320591,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-0770-9990","PersID":38701,"InsID":null},{"AutName":"Kashman","Firstname":"Yoel","Initials":"Y.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":234256,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Carmeli","Firstname":"Shmuel","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":285812,"AutID":318931,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":332538,"LibID":36,"BRefID":293748,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"332538","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"American Chemical Society","City":"Washington DC"},{"PublName":"American Society of Pharmacognosy","City":"Washington DC"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":285812,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":285812,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1021/acs.jnatprod.7b00028","externalID":"10.1021/acs.jnatprod.7b00028","URLTypeCode":"DOI","URLID":62641,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2018-03-12 21:25:44.307000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2019-07-09 08:58:36.087000","timezone_type":3,"timezone":"Europe/Brussels"}}}