{"refrec":{"BRefID":293762,"RR":"<b>Montero-Alejo, V.; Corzo, G.; Porro-Suardiaz, J.; Pardo-Ruiz, Z.; Perera, E.; Rodriguez-Viera, L.; Sanchez-Diaz, G.; Alvarez, C.; Peigneur, S.; Tytgat, J.; Perdomo-Morales, R.</b> (2017). Panusin represents a new family of β-defensin-like peptides in invertebrates. <i>Dev. Comp. Immunol. 67</i>: 310-321. <a href=\"https://dx.doi.org/10.1016/j.dci.2016.09.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.dci.2016.09.002</a>","BEntID":285826,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Dev. Comp. Immunol. 67</i>: 310-321. <a href=\"https://dx.doi.org/10.1016/j.dci.2016.09.002\" target=\"_blank\">https://dx.doi.org/10.1016/j.dci.2016.09.002</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Montero-Alejo, V.; Corzo, G.; Porro-Suardiaz, J.; Pardo-Ruiz, Z.; Perera, E.; Rodriguez-Viera, L.; Sanchez-Diaz, G.; Alvarez, C.; Peigneur, S.; Tytgat, J.; Perdomo-Morales, R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Montero-Alejo, V. <i>et al.</i>","Englishabstract":"Beta_defensin have been solely found in vertebrates until beta-defensin-like peptides were described as transcript isoforms in two species of <i>Panulirus</i> genus. They were considered as putative antimicrobials since their biological activity have not been demonstrated. Here we purified and characterized a defensin-like peptide from the hemocytes of spiny lobster <i>P. argus</i>, hereafter named panusin. Structurally, panusin presents a cysteine-stabilized alpha/beta motif, and is prone to form homodimers. Biological activity of panusin showed broad-spectrum antimicrobial activity, characterized for being strikingly salt-resistant. Panusin did not showed hemolytic activity but was demonstrated its binding capacity to different lipid membrane models, indicating amphipathicity of beta-sheet core as driving force for its antimicrobial activity. Panusin is considered a new kind of arthropod defensin which share structural and biological features with beta-defensin from vertebrates. The presence of beta-defensin like peptides in crustacean might suggest the emergence of the evolutionary relationship of beta-defensins from vertebrates.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Panusin represents a new family of β-defensin-like peptides in invertebrates","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:32:23.117068","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Invertebrate; Antimicrobial activity; Secondary structure; Proteinpurification; Membrane binding; Defensins","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2019-07-10","DateCreate":"2018-03-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000390071200031","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.dci.2016.09.002"},"refs":null,"anarec":{"AnaID":293762,"PubliDate":2017,"Pagination":"310-321","XtraPublOfAnaID":null,"ISBN":null,"Volume":"67","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":120980,"SerRR":"Developmental and Comparative Immunology. 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