{"refrec":{"BRefID":295651,"RR":"<b>Esquivel-Hernandez, D.A.; Rodriguez-Rodriguez, J.; Cuéllar-Bermúdez, S.P.; Garcia-Perez, J.S.; Mancera-Andrade, E.I.; Núñez-Echevarría, J.E.; Ontiveros-Valencia, A.; Rostro-Alanis, M.; Garcia-Garcia, R.M.; Torres, J.A.; Chen, W.N.; Parra-Saldivar, R.</b> (2017). Effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from <i>Arthrospira platensis</i>. <i>Mar. Drugs 15(6)</i>: 174. <a href=\"https://dx.doi.org/10.3390/md15060174\" target=\"_blank\">https://dx.doi.org/10.3390/md15060174</a>","BEntID":287738,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 15(6)</i>: 174. <a href=\"https://dx.doi.org/10.3390/md15060174\" target=\"_blank\">https://dx.doi.org/10.3390/md15060174</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Esquivel-Hernandez, D.A.; Rodriguez-Rodriguez, J.; Cuéllar-Bermúdez, S.P.; Garcia-Perez, J.S.; Mancera-Andrade, E.I.; Núñez-Echevarría, J.E.; Ontiveros-Valencia, A.; Rostro-Alanis, M.; Garcia-Garcia, R.M.; Torres, J.A.; Chen, W.N.; Parra-Saldivar, R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Esquivel-Hernandez, D.A. <i>et al.</i>","Englishabstract":"<i>Arthrospira platensis</i> was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO<sub>2</sub>). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett–Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0.10 µg/g of β-carotene, 1.44 ± 0.10 µg/g of lutein and 32.11 ± 0.12 mg/g of fatty acids with 39.38% of palmitic acid, 20.63% of linoleic acid and 30.27% of γ-linolenic acid. <i>A. platensis</i> extracts had an antioxidant activity of 76.47 ± 0.71 µg GAE/g by Folin–Ciocalteu assay, 0.52 ± 0.02, 0.40 ± 0.01 and 1.47 ± 0.02 µmol TE/g by DPPH, FRAP and TEAC assays, respectively. These extracts showed antimicrobial activity against <i>Staphylococcus aureus</i> ATCC 25923, <i>Pseudomonas aeruginosa</i> ATCC 27853, <i>Escherichia coli</i> ATCC 25922 and <i>Candida albicans</i> ATCC 10231. Overall, co-solvent was the most significant factor for all measured effects (<i>p</i> &lt; 0.05). <i>Arthrospira platensis</i> represents a sustainable source of bioactive compounds through SFE using the following extraction parameters P: 450 bar, CX: 11 g/min, SX: 15 min, DX: 25 min, T: 60 °C and Di: 35 g.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from <i>Arthrospira platensis</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-05 01:31:12.518325","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Arthrospira platensis; supercritical fluid extraction; antioxidants;antimicrobials; bioactive compounds; nutraceuticals; -linolenic acid;tocopherol; -carotene; riboflavin","OtherDescriptors":null,"Notes":null,"AnaPub":2017,"MonPub":null,"DateUpdate":"2018-06-05","DateCreate":"2018-05-15","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000404526900029","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md15060174"},"refs":null,"anarec":{"AnaID":295651,"PubliDate":2017,"Pagination":"174","XtraPublOfAnaID":null,"ISBN":null,"Volume":"15","Issue":"6","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. 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