{"refrec":{"BRefID":2964,"RR":"<b>Gapasin, R.S.J.; Nelis, H.; Chair, M.; Sorgeloos, P.</b> (1996). Drug assimilation in the tissue of European sea bass (<i>Dicentrarchus labrax</i>) fry delivered orally through bioencapsulation. <i>J. Appl. Ichthyol. 12(1)</i>: 39-42. <a href=\"https://dx.doi.org/10.1111/j.1439-0426.1996.tb00057.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1439-0426.1996.tb00057.x</a>","BEntID":2964,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>J. Appl. Ichthyol. 12(1)</i>: 39-42. <a href=\"https://dx.doi.org/10.1111/j.1439-0426.1996.tb00057.x\" target=\"_blank\">https://dx.doi.org/10.1111/j.1439-0426.1996.tb00057.x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Gapasin, R.S.J.; Nelis, H.; Chair, M.; Sorgeloos, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Gapasin, R.S.J. <i>et al.</i>","Englishabstract":"Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (<i>Dicentrarchus labrax</i>) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in oil emulsion (Selco) at 20% and 40% concentrations (w/w) were bioencapsulated in <i>Artemia</i> (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentration in the tissue were analysed by high-performance liquid chromatography (HPLC). Fish fed 40% 'medicated' <i>Artemia</i> assimilated significantly higher levels of chemotherapeutics compared with those fed 20% 'medicated' <i>Artemia</i> . Chemotherapeutics given at 40% reached peak levels (19.3 µg TMP/g DW and 23.31 µg SMX/g DW) within 2h while those at 20% peaked (8.74 µg TMP/g DW and 6.73 µg SMX/g DW) after 5h. TWP persisted in the tissues longer (up to 72h) than SMX (12-16h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Drug assimilation in the tissue of European sea bass (<i>Dicentrarchus labrax</i>) fry delivered orally through bioencapsulation","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-06 01:31:51.821121","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1996,"MonPub":null,"DateUpdate":"2018-03-12","DateCreate":"2000-08-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1996UK20900007","VABBcode":null,"OpenAcc":0,"DOI":"10.1111/j.1439-0426.1996.tb00057.x"},"refs":null,"anarec":{"AnaID":2964,"PubliDate":1996,"Pagination":"39-42","XtraPublOfAnaID":null,"ISBN":null,"Volume":"12","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43023,"SerRR":"Journal of Applied Ichthyology = Zeitschrift für angewandte Ichthyologie. 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