{"refrec":{"BRefID":296589,"RR":"<b>Bagai, A.</b> (2018). Photocatalytic fluorination of benzylic C-H bonds and studies towards the synthesis of salinosporamide C. MSc Thesis. Simon Fraser University: Burnaby.  84 pp.","BEntID":288678,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". MSc Thesis. Simon Fraser University: Burnaby.  84 pp.","DocTypID":5,"DocType":"Book/Monograph","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bagai, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bagai, A.","Englishabstract":"Fluorinated pharmaceuticals comprise nearly a quarter of the total pharmaceutical market. However, current fluorination methods and reagents lack a certain range particularly in the fluorination of C-H bonds. The first part of this thesis describes the fluorination of benzylic C-H bonds utilizing the hydrogen abstracting ability of a classic photocatalyst and a bench stable fluorine atom transfer reagent. The simple and straightforward reaction demonstrates a wide range of tolerance to functionalities and provides access to fluorinated compounds in moderate to good yield. The second part of this thesis consists of research towards the synthesis of a marine natural product, salinosporamide C, which was discovered in 2002 and has yet to be synthesized. The true activity of the compound is unknown, however its biogenetically related counterpart salinosporamide A is considered a potent 20S proteasome inhibitor. Though the total synthesis of salinosporamide C was not accomplished, an advanced intermediate was successfully synthesized and the groundwork for a successful synthesis of this natural product was completed.","AbstractOtherLang":null,"BibLvlCode":"M","StandardTitle":"Photocatalytic fluorination of benzylic C-H bonds and studies towards the synthesis of salinosporamide C","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Tetrabutylammonium decatungsta; N-fluorobenzenesulfonimide; Marine natural products; Salinosporamide  ","OtherDescriptors":null,"Notes":null,"AnaPub":null,"MonPub":2018,"DateUpdate":"2018-06-04","DateCreate":"2018-06-04","SecASFANote":null,"ConfID":null,"PeerRev":0,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1},"refs":null,"anarec":null,"monrec":{"MonID":296589,"ISBN":null,"PubliDate":2018,"IssueDate":null,"Volume":null,"Issue":null,"Pagination":"84","Place":"Burnaby","Edition":null,"BRefXtra":null,"BRefXtraRR":null,"SerID":null,"SerRR":null,"Ser2BRefID":null,"Ser2RR":null,"StandardTitleSer":null,"ISSN":null,"AbbrevSer":null,"Degree":"MSc","ThesisID":296589,"InsID":null,"Acronym":null,"FullStandardName":null,"ToPubliDate":null,"SerNotes":null,"eISBN":null,"Pages":84},"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Bagai","Firstname":"Abhimanyu","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":288678,"AutID":331985,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":313877,"LibID":36,"BRefID":296589,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"313877","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":[{"LitStyID":7,"Style":"Dissertation"}],"thespers":null,"arch2discl":null,"SERpubls":null,"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Photocatalysis","ThestID":87113,"Acronym":"CSA","ThesTermPath":"Photocatalysis"}],"thestermsASFA":[{"ThesaurusTerm":"Photocatalysis"}],"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"VLIZ Acknowledged Publications","ShortName":"VLIZ ackn"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"941":{"SpName":"LifeWatch Species Information Backbone","SpColID":941,"ParSpColID":39,"TopParID":39,"ShortName":"LifeWatch Species Information Backbone","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone"},"39":{"SpName":"VLIZ Acknowledged Publications","SpColID":39,"ParSpColID":null,"TopParID":null,"ShortName":"VLIZ ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ ackn"},"507":{"SpName":"World Register of Marine Species","SpColID":507,"ParSpColID":null,"TopParID":null,"ShortName":"WoRMS website","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"WoRMS website"},"915":{"SpName":"World Register of Marine Species (WoRMS) acknowledged","SpColID":915,"ParSpColID":941,"TopParID":39,"ShortName":"WoRMS ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn"},"947":{"SpName":"WoRMS ackn - 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