{"refrec":{"BRefID":297886,"RR":"<b>Fedorov, S.N.; Shubina, L.K.; Balaneva, N.N.; Bode, A.M.; Stonik, V.A.; Dong, Z.</b> (2006). Evaluation of cancer-preventive activity and structure–activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian <i>Aplidium glabrum</i>, and its synthetic analogs. <i>Pharmaceutical Research 23(1)</i>: 70-81. <a href=\"https://dx.doi.org/10.1007/s11095-005-8813-4\" target=\"_blank\">https://dx.doi.org/10.1007/s11095-005-8813-4</a>","BEntID":289974,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Pharmaceutical Research 23(1)</i>: 70-81. <a href=\"https://dx.doi.org/10.1007/s11095-005-8813-4\" target=\"_blank\">https://dx.doi.org/10.1007/s11095-005-8813-4</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Fedorov, S.N.; Shubina, L.K.; Balaneva, N.N.; Bode, A.M.; Stonik, V.A.; Dong, Z.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Fedorov, S.N. <i>et al.</i>","Englishabstract":"PURPOSE:3-Demethylubiquinone Q2 was isolated from the ascidian <i>Aplidium glabrum</i>. The cancer-preventive properties and the structure-activity relationship for 3-demethylubiquinone Q2 and 12 of its synthetic analogs are reported.METHODS:Compounds, having one or several di- or triprenyl substitutions and quinone moieties with methoxyls in different positions, were synthesized. The cancer-preventive properties of compounds and were tested in JB6 Cl41 mouse skin cells, using a variety of assessments, including the methanethiosulfonate (MTS) assay, flow cytometry, and soft agar assay. Statistical nonparametric methods were used to confirm statistical significance.RESULTS:All quinones tested were shown to inhibit JB6 Cl41 cell transformation, to induce apoptosis, AP-1, and NF-kappaB activity, and to inhibit p53 activity. The most promising effects were indicated for compounds containing two isoprene units in a side chain and a methoxyl group at the para-position to a polyprenyl substitution.CONCLUSIONS:Quinones and demonstrated cancer-preventive activity in JB6 Cl41 cells, which may be attributed to the induction of p53-independent apoptosis. These activities depended on the length of side chains and on the positions of the methoxyl groups in the quinone part of the molecule.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Evaluation of cancer-preventive activity and structure–activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian <i>Aplidium glabrum</i>, and its synthetic analogs","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"marine prenylated quinones; cancer prevention; apoptosis; nuclear factor; structure-activity relationship","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2018-07-06","DateCreate":"2018-07-06","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000235135400006","VABBcode":null,"OpenAcc":1,"DOI":"10.1007/s11095-005-8813-4"},"refs":null,"anarec":{"AnaID":297886,"PubliDate":2006,"Pagination":"70-81","XtraPublOfAnaID":null,"ISBN":null,"Volume":"23","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":276244,"SerRR":"Pharmaceutical Research. 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