{"refrec":{"BRefID":300228,"RR":"<b>Yan, P.; Ritt, D.A.; Zlotkowski, K.; Bokesch, H.R.; Reinhold, W.C.; Schneekloth, J.S.; Morrison, D.K.; Gustafson, K.R.</b> (2018). Macrophilones from the marine hydroid <i>Macrorhynchia philippina</i> can inhibit ERK cascade signaling. <i>J. Nat. Prod. 81(7)</i>: 1666-1672. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.8b00343\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.8b00343</a>","BEntID":292449,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>J. Nat. Prod. 81(7)</i>: 1666-1672. <a href=\"https://dx.doi.org/10.1021/acs.jnatprod.8b00343\" target=\"_blank\">https://dx.doi.org/10.1021/acs.jnatprod.8b00343</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yan, P.; Ritt, D.A.; Zlotkowski, K.; Bokesch, H.R.; Reinhold, W.C.; Schneekloth, J.S.; Morrison, D.K.; Gustafson, K.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yan, P. <i>et al.</i>","Englishabstract":"Six new macrophilone-type pyrroloiminoquines were isolated and identified from an extract of the marine hydroid <i>Macrorhynchia philippina</i>. The proton-deficient and heteroatom-rich structures of macrophilones B–G (2–7) were elucidated by spectroscopic analysis and comparison of their data with those of the previously reported metabolite macrophilone A (1). Compounds 1–7 are the first pyrroloiminoquines to be reported from a hydroid. The macrophilones were shown to inhibit the enzymatic conjugation of SUMO to peptide substrates, and macrophilones A (1) and C (3) exhibit potent and selective cytotoxic properties in the NCI-60 anticancer screen. Bioinformatic analysis revealed a close association of the cytotoxicity profiles of 1 and 3 with two known B-Raf kinase inhibitory drugs. While compounds 1 and 3 showed no kinase inhibitory activity, they resulted in a dramatic decrease in cellular protein levels of selected components of the ERK signal cascade. As such, the chemical scaffold of the macrophilones could provide small-molecule therapeutic leads that target the ERK signal transduction pathway.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Macrophilones from the marine hydroid <i>Macrorhynchia philippina</i> can inhibit ERK cascade signaling","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-23 01:32:50.585144","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2022-07-18","DateCreate":"2018-08-13","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000440505900022","VABBcode":null,"OpenAcc":0,"DOI":"10.1021/acs.jnatprod.8b00343"},"refs":null,"anarec":{"AnaID":300228,"PubliDate":2018,"Pagination":"1666-1672","XtraPublOfAnaID":null,"ISBN":null,"Volume":"81","Issue":"7","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43089,"SerRR":"Journal of Natural Products. 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