Document of bibliographic reference 300677

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease

Abstract

Cnidaria provide the largest source of bioactive peptides for new drug development. The venoms contain enzymes, potent pore-forming toxins and neurotoxins. The neurotoxins can immobilize predators rapidly when discharged via modifying sodium-channel-gating or blocking the potassium channel during the repolarization stage. Most cnidarian neurotoxins remain conserved under the strong influence of negative selection. Neuroactive peptides targeting the central nervous system through affinity with ion channels could provide insight leading to drug treatment of neurological diseases, which arise from ion channel dysfunctions. Although marine resources offer thousands of possible peptides, only one peptide derived from Cnidaria: ShK-186, also named dalazatide, has reached the pharmaceutical market. This review focuses on neuroprotective agents derived from cnidarian neurotoxic peptides.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000460194900020

Bibliographic citation

Liao, Q.; Feng, Y.; Yang, B.; Lee, S.M.-Y. (2019). Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease. Drug Discovery Today 24(1): 189-197. https://dx.doi.org/10.1016/j.drudis.2018.08.011

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true