{"refrec":{"BRefID":301258,"RR":"<b>Kumar, V.; Baruah, K.; Nguyen, D.V.; Smagghe, G.; Vossen, E.; Bossier, P.</b> (2018). Phloroglucinol-mediated Hsp70 production in crustaceans: protection against <i>Vibrio parahaemolyticus</i> in <i>Artemia franciscana</i> and <i>Macrobrachium rosenbergii</i>. <i>Frontiers in Immunology 9</i>: 1091. <a href=\"https://dx.doi.org/10.3389/fimmu.2018.01091\" target=\"_blank\">https://dx.doi.org/10.3389/fimmu.2018.01091</a>","BEntID":293497,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Frontiers in Immunology 9</i>: 1091. <a href=\"https://dx.doi.org/10.3389/fimmu.2018.01091\" target=\"_blank\">https://dx.doi.org/10.3389/fimmu.2018.01091</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kumar, V.; Baruah, K.; Nguyen, D.V.; Smagghe, G.; Vossen, E.; Bossier, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kumar, V. <i>et al.</i>","Englishabstract":"The halophilic aquatic bacterium, <i>Vibrio parahaemolyticus</i>, is an important aquatic pathogen, also capable of causing acute hepatopancreatic necrosis disease (AHPND) in shrimp resulting in significant economic losses. Therefore, there is an urgent need to develop anti-infective strategies to control AHPND. The gnotobiotic <i>Artemia</i> model is used to establish whether a phenolic compound phloroglucinol is effective against the AHPND strain <i>V. parahaemolyticus</i> MO904. We found that pretreatment with phloroglucinol, at an optimum concentration (30 µM), protects axenic brine shrimp larvae against <i>V. parahaemolyticus</i> infection and induced heat shock protein 70 (Hsp70) production (twofolds or more) as compared with the control. We further demonstrated that the <i>Vibrio</i>-protective effect of phloroglucinol was caused by its prooxidant effect and is linked to the induction of Hsp70. In addition, RNA interference confirms that phloroglucinol-induced Hsp70 mediates the survival of brine shrimp larvae against <i>V. parahaemolyticus</i> infection. The study was validated in xenic <i>Artemia</i> model and in a <i>Macrobrachium rosenbergii</i> system. Pretreatment of xenic brine shrimp larvae (30 µM) and <i>Macrobrachium</i> larvae (5 µM) with phloroglucinol increases the survival of xenic brine shrimp and <i>Macrobrachium</i> larvae against subsequent <i>V. parahaemolyticus</i> challenge. Taken together, our study provides substantial evidence that the prooxidant activity of phloroglucinol induces Hsp70 production protecting brine shrimp, <i>A. franciscana</i>, and freshwater shrimp, <i>M. rosenbergii</i>, against the AHPND <i>V. parahaemolyticus</i> strain MO904. Probably, phloroglucinol treatment might become part of a holistic strategy to control AHPND in shrimp.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Phloroglucinol-mediated Hsp70 production in crustaceans: protection against <i>Vibrio parahaemolyticus</i> in <i>Artemia franciscana</i> and <i>Macrobrachium rosenbergii</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"gnotobiotic Artemia; Vibrio parahaemolyticus; phloroglucinol; heat shockprotein 70; Macrobrachium rosenbergii","OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2022-08-18","DateCreate":"2018-09-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000432685900001","VABBcode":null,"OpenAcc":1,"DOI":"10.3389/fimmu.2018.01091"},"refs":null,"anarec":{"AnaID":301258,"PubliDate":2018,"Pagination":"1091","XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":268438,"SerRR":"Frontiers in Immunology. Frontiers Research Foundation: Lausanne.  e-ISSN 1664-3224","StandardTitleSer":"Frontiers in Immunology","ISSN":null,"AbbrevSer":null,"StandardTitleMon":null,"StartPage":16,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":337719,"RefStrFull":"<b>Kumar, V.; Baruah, K.; Nguyen, D.V.; Smagghe, G.; Vossen, E.; Bossier, P.</b> (2020). Corrigendum: Phloroglucinol-mediated Hsp70 production in crustaceans: protection against <i>Vibrio parahaemolyticus</i> in <i>Artemia franciscana</i> and <i>Macrobrachium rosenbergii</i>. <i>Frontiers in Immunology 11</i>: 1860. <a href=\"https://hdl.handle.net/10.3389/fimmu.2020.01860\" target=\"_blank\">https://hdl.handle.net/10.3389/fimmu.2020.01860</a>","RelID":4,"Relation":"Related to","StandardTitle":"Corrigendum: Phloroglucinol-mediated Hsp70 production in crustaceans: protection against <i>Vibrio parahaemolyticus</i> in <i>Artemia franciscana</i> and <i>Macrobrachium rosenbergii</i>"}],"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Kumar","Firstname":"Vikash","Initials":"V.","Affiliation":"Laboratory of Aquaculture & Artemia Reference Center, Department of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Ghent University","Discriminator":null,"CorporateFlag":0,"BEntID":293497,"AutID":344005,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"ARC","InsFSN":"Universiteit Gent; 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