{"refrec":{"BRefID":301999,"RR":"<b>de Lorgeril, J.; Lucasson, A.; Petton, B.; Toulza, E.; Montagnani, C.; Clerissi, C.; Vidal-Dupiol, J.; Chaparro, C.; Galinier, R.; Escoubas, J.-M.; Haffner, Ph.; Dégremont, L.; Charrière, G.M.; Lafont, M.; Delort, A.; Vergnes, A.; Chiarello, M.; Faury, N.; Rubio, T.; Leroy, M.A.; Pérignon, A.; Régler, D.; Morga, B.; Alunno-Bruscia, M.; Boudry, P.; Le Roux, F.; Destoumieux-Garzon, D.; Gueguen, Y.; Mitta, G.</b> (2018). Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters. <i>Nature Comm. 9(1)</i>: 14 pp. <a href=\"https://dx.doi.org/10.1038/s41467-018-06659-3\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-018-06659-3</a>","BEntID":294240,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 9(1)</i>: 14 pp. <a href=\"https://dx.doi.org/10.1038/s41467-018-06659-3\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-018-06659-3</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"de Lorgeril, J.; Lucasson, A.; Petton, B.; Toulza, E.; Montagnani, C.; Clerissi, C.; Vidal-Dupiol, J.; Chaparro, C.; Galinier, R.; Escoubas, J.-M.; Haffner, Ph.; Dégremont, L.; Charrière, G.M.; Lafont, M.; Delort, A.; Vergnes, A.; Chiarello, M.; Faury, N.; Rubio, T.; Leroy, M.A.; Pérignon, A.; Régler, D.; Morga, B.; Alunno-Bruscia, M.; Boudry, P.; Le Roux, F.; Destoumieux-Garzon, D.; Gueguen, Y.; Mitta, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"de Lorgeril, J. <i>et al.</i>","Englishabstract":"Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of <i>Crassostrea gigas</i>, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-06 01:33:52.846815","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2018,"MonPub":null,"DateUpdate":"2018-10-12","DateCreate":"2018-10-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000447075700003","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-018-06659-3"},"refs":null,"anarec":{"AnaID":301999,"PubliDate":2018,"Pagination":"14 pp","XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. Nature Publishing Group: London.  ISSN 2041-1723; e-ISSN 2041-1723","StandardTitleSer":"Nature Communications","ISSN":"2041-1723","AbbrevSer":"Nature Comm.","StandardTitleMon":null,"StartPage":null,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"de Lorgeril","Firstname":"Julien","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346846,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Lucasson","Firstname":"Aude","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346847,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Petton","Firstname":"Bruno","Initials":"B.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346848,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Toulza","Firstname":"Eve","Initials":"E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":210020,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Montagnani","Firstname":"Caroline","Initials":"C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346849,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Clerissi","Firstname":"Camille","Initials":"C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":232371,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vidal-Dupiol","Firstname":"Jeremie","Initials":"J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":270193,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Chaparro","Firstname":"Cristian","Initials":"C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":271016,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Galinier","Firstname":"Richard","Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346850,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Escoubas","Firstname":"Jean-Michel","Initials":"J.-M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346851,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Haffner","Firstname":"Philippe","Initials":"Ph.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":35926,"OrderNr":11,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Dégremont","Firstname":"Lionel","Initials":"L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":204431,"OrderNr":12,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Charrière","Firstname":"Guillaume","Initials":"G.M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346852,"OrderNr":13,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Lafont","Firstname":"Maxime","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346853,"OrderNr":14,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Delort","Firstname":"Abigaïl","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346854,"OrderNr":15,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vergnes","Firstname":"Agnès","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346855,"OrderNr":16,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Chiarello","Firstname":"Marlène","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346856,"OrderNr":17,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Faury","Firstname":"Nicole","Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":13184,"OrderNr":18,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Rubio","Firstname":"Tristan","Initials":"T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346857,"OrderNr":19,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Leroy","Firstname":"Marc","Initials":"M.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346858,"OrderNr":20,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Pérignon","Firstname":"Adeline","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346859,"OrderNr":21,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Régler","Firstname":"Denis","Initials":"D.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346860,"OrderNr":22,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Morga","Firstname":"Benjamin","Initials":"B.","Affiliation":"IFREMER, LGP, F-17390 La Tremblade, France.","Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":293348,"OrderNr":23,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Alunno-Bruscia","Firstname":"Marianne","Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":74511,"OrderNr":24,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Boudry","Firstname":"Pierre","Initials":"P.","Affiliation":"IFREMER, UMR Physiol & Ecophysiol Mollusques Marins M100, F-29280 Plouzane, France.","Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":293277,"OrderNr":25,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Le Roux","Firstname":"Frédérique","Initials":"F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346861,"OrderNr":26,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Destoumieux-Garzon","Firstname":"Delphine","Initials":"D.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346862,"OrderNr":27,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Gueguen","Firstname":"Yannick","Initials":"Y.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346863,"OrderNr":28,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Mitta","Firstname":"Guillaume","Initials":"G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":294240,"AutID":346864,"OrderNr":29,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":319907,"LibID":36,"BRefID":301999,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"319907","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Nature Publishing Group","City":"London"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":294240,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":294240,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1038/s41467-018-06659-3","externalID":"10.1038/s41467-018-06659-3","URLTypeCode":"DOI","URLID":68224,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2018-10-12 08:26:51.010000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Chisala, Chilekwa, C.","updSesDate":{"date":"2018-10-12 08:26:51.010000","timezone_type":3,"timezone":"Europe/Brussels"}}}